methyl chloroformate

methyl chloroformate

[′meth·əl ¦klȯrə¦fȯr‚māt]
(organic chemistry)
ClCOOCH3 A toxic, corrosive, colorless liquid with a boiling point of 71.4°C; soluble in benzene, ether, and methanol; used as a lacrimator in military poison gas and for insecticides. Also known as methyl chlorocarbonate.
References in periodicals archive ?
Next, the amino acids were eluted from the tips with 100 ul of freshly prepared 1:1 (v/v) 8M ammonium hydroxide:methanol into 250 ul conical glass vials (sold as GC auto sampler inserts).The analyte in 1:1 (v/v) 8M ammonium hydroxide:methanol was dried using nitrogen gas and then 25 ul of methanol was added in the tube and derivatized by using of 2.5 ul of pyridine and 2.5 ul of methyl chloroformate into the 250 ul glass vial [28].
D Cohen, Microscale analysis of amino acids using gas chromatography-mass spectrometry after methyl chloroformate derivatization.
The method incorporates derivatization with methyl chloroformate, separation of the analytes by ion-pair HPLC, and detection by electrospray ionization tandem mass spectrometry (MS).
Analytical grade methanol and methyl chloroformate were obtained from Merck.
One hundred microliters of each urine sample was used for the derivatization with methyl chloroformate. Methyl chloroformate reacts with primary, secondary, and tertiary amino groups, but not with quaternary amino groups.
Derivatization was started by the addition of 20 [micro]L of methyl chloroformate and the mixture was vortex-mixed.
To measure the carnitine biosynthesis intermediates in urine, samples were first derivatived with methyl chloroformate. This enabled the separation of interfering compounds, mainly amino acids, from the compounds of interest.
Pietrogrande, Gas Chromatography-Mass Spectrometry Analysis of Amino Acid Enantiomers as Methyl Chloroformate Derivatives: Application to Space Analysis J.
To a cold solution of 2-amino thiazole (1a) (0.001 mol) in dry pyridine (15 mL) at 0-5 C the appropriate alkyl chloroformate (2a-d) (0.001 mol) namely, methyl chloroformate, ethyl chloroformate, propyl chloroformate and isobutyl chloroformate was added.
Reaction of 2-aminothiazoles (1a-b) with various alkyl chloroformates (2a-d), namely methyl chloroformate, ethyl chloroformate, propyl chloroformate and isobutyl chloroformate under dry conditions and in presence of pyridine [33] or triethylamine as the basic catalyst, afforded the corresponding carbamates (3a-e).