methylate

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methylate

[′meth·ə‚lāt]
(organic chemistry)
References in periodicals archive ?
DNA methylation is different from histone methylation, with the effects of the latter being more transient.
10) The structure of the chromatin regulates transcription, and DNA methylation affects chromatin stability.
Our results demonstrated that MSAP technique is a powerful technique to detect large-scale DNA methylation in the maize genome and that DNA methylation is involved in epigenetic regulation of maize internode elongation.
DNA methylation one of the first discovered epigenetic variations could generate phenotypic variations through tuning expression of genes in a tissue-specific or a development stage-specific pattern (Angers et al.
3]), predominantly where cytosine bases occur consecutively, DNA methylation was first confirmed to occur in human cancer in 1983, and has since been observed in many other illnesses and health conditions.
In generics, imprinting describes the condition where one of the two alleles of a typical gene pair is silenced by an epigenetic process such as methylation or acetylation.
sup][4] LINE-1 transcription and retrotransposition are prevented in normal somatic cells by a variety of control mechanisms, including methylation of LINE-1, specifically LINE-1 promoters.
Moreover, several studies have implicated DNA methylation as an additional mechanism controlling telomere length (TL).
Although the process of methylation is relatively easy, it is clearly crucial for life and health because it plays an essential role in maintaining cellular function.
In molecular diagnosis, nucleic acid sequencing is considered the gold standard for methylation detection, but this may not be suitable for routine clinical testing as it is laborious and expensive.
Plasma total homocysteine (tHcy), AdoMet, and AdoHcy concentrations, as well as leukocyte DNA methylation status, were evaluated in vascular disease and control groups.
A plasmacytoma-derived cell line, HS-Sultan (CRL1484; American Type Culture Collection), previously shown to have p16 methylation by Southern blot analysis (12), was used as a methylated control for MSP.