methylate

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methylate

[′meth·ə‚lāt]
(organic chemistry)
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demonstrated that DLEC1 was downregulated or silenced in most gastric cell lines due to promoter methylation, whereas it was broadly expressed in normal stomach tissues [16].
The purpose of our study is to investigate the relationship of DLEC1 methylation with clinicopathologic variables and determine whether DLEC1 methylation has any prognostic significance in patients with gastric cancer.
To identify the possible genetic difference of Kazak population from Han population, we hypothesized that differential expression and CpG methylation of miR-375 may be an ethnic-related factor that influences the incidence and severity of T2DM in this two ethnic groups.
In the analysis of the Chinese Kazak T2DM samples, whether the differences in miR-375 gene methylation were differently depending on clinical parameters was determined by the Mann-Whitney test.
Objective: The objective of the study was to summarize the role of DNA methylation in the development and metastasis of uveal melanoma (UM).
Interestingly, under all the examined cell lines, we observed a negative correlation of the methylation patterns between RNA [m.sup.5]C methylation and DNA [m.sup.5]C under the CpG context, and the RNA [m.sup.5]C methylations are enriched on mitochondrial transcriptome.
Abnormal methylations of cytokines gene in several key regions, such as TSS, CpG islands, and the neighbors, were likely to directly affect the transcription and gene function and contributed to the downstream signal network.
Histone modifications occur due to methylation, acetylation, and phosphorylation.
Although the process of methylation is relatively easy, it is clearly crucial for life and health because it plays an essential role in maintaining cellular function.
Our results demonstrated that MSAP technique is a powerful technique to detect large-scale DNA methylation in the maize genome and that DNA methylation is involved in epigenetic regulation of maize internode elongation.
In molecular diagnosis, nucleic acid sequencing is considered the gold standard for methylation detection, but this may not be suitable for routine clinical testing as it is laborious and expensive.