methylate

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methylate

[′meth·ə‚lāt]
(organic chemistry)
References in periodicals archive ?
First group is consisted of multiple chromosomal alterations together with P53 mutations and MSI, CpG island methylator phenotype (CIMP) on a genome wide level and BRAF mutations are observed in the second group (13,14).
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
Issa, "CpG island methylator phenotype in colorectal cancer," Proceedings of the National Academy of Sciences of the United States of America, vol.
CpG island methylator phenotype (CIMP) pathway: The CIMP pathway is the most recent addition to the CRC etiologies [97].
This cancer has usually been viewed as a homogeneous entity rather than a complex heterogeneous disease developing through multiple genetic and epigenetic abnormalities, such as defective DNA mismatch repair (dMMR) and the CpG island methylator phenotype (CIMP) [144].
Wang et al., "CpG island methylator phenotype associated with tumor recurrence in tumor-node-metastasis stage I hepatocellular carcinoma," Annals of Surgical Oncology, vol.
Recent evidence suggests that accumulation of genetic and epigenetic alterations in malignant colonic cells progresses through at least three distinct pathways: chromosomal instability (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP) [6-8].
Compared with other cancers, these interval cancers were much more likely to have CpG island methylator phenotype (CIMP), microsatellite instability, and high levels of LINE-1 methylation--all indicators of increased tumor aggressiveness.
A subset of colorectal cancers exhibit promoter methylation in multiple genes; these tumors are referred to as the CpG island methylator phenotype (CIMP) (Toyota et al.
"As compared with the distal colon, the proximal colon poses a more difficult challenge for colorectal cancer control because of limitations in bowel preparation, a greater prevalence of advanced serrated adenomas, which are harder to detect than conventional adenomas, and biologic differences, including a greater incidence of BRAF mutation, micro-satellite instability, and CpG island methylator phenotype (CIMP)," the study's researchers explained.
Este fenomeno de hipermetilacion se conoce como fenotipo de metilacion de las islas CpG o CIMP (por la sigla en ingles de CpG island methylator phenotype).
The CpG island methylator phenotype is characterized by DNA hypermethylation in the promoters of tumor suppressor genes with silencing of transcription.