Methylene Blue

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methylene blue

[′meth·ə‚lēn ′blü]
(organic chemistry)
Dark green crystals or powder; soluble in water (deep blue solution), alcohol, and chloroform; C16H18N3SCl·3H2 O used in medicine; (C16H18N3SCl)2·ZnCl2·H2 O used as a textile dye, biological stain, and indicator. Also known as methylthionine chloride.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Methylene Blue


an organic dye of the thiazine group, used in medicine as an antiseptic and as an antidote for certain types of poisoning.

Methylene blue is applied externally for irrigation and as an ointment for purulent skin conditions; it is taken internally to treat inflammations of the urinary bladder. In addition, it is administered intravenously in glucose solution for cases of hydrocyanic acid, carbon monoxide, and hydrogen sulfide poisoning. Industrially, methylene blue is used in coloring paper, as well as in pencils and printer’s ink.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Punjabi, Silver(I) Catalyzed photochemical oxidation of methylene blue and safranine-O by peroxydisulphate: A green chemical approach, Int.
The mechanism of action of methylene blue in the treatment of methemoglobinemia is through the NADPH-MetHb reductase system.
Patient was given methylene blue infusion of 1 mg/kg body weight over 20 mins, SP[O.sub.2] improved to 99% at room air.
The positive result for the presence of AFB was confirmed using ZN technique which includes strong carbol fuschin as primary stain, 20% sulphuric acid as decolorizer and 0.1% methylene blue as counter stain (7).
The parabasal cells were small round cells with a high nuclear to cytoplasmic ratio and can be seen clearly in clusters when stained with methylene blue. The intermediate cells varied in size and shape as some can be oval with prominent nucleus and others polygonal with lesser nucleus to cytoplasmic ratio .These cells were clearly shown with the Papanicolaou stain than other stains.
Methylene blue is used for sentinel node biopsies as it carries a lower risk of allergic reaction than the alternative blue dyes (1,2).
Patients were randomly assigned to receive a full dose of the methylene blue dye, a half dose, or placebo.
Here, we modeled hindlimb IR by clamping left femoral artery for 4 h followed by 4 h of reperfusion in rats, and the effects of methylene blue treatment were evaluated.
The methylene blue has a large polar organic molecule [C.sub.16][H.sub.18][N.sub.3][S.sup.+] that can be adsorbed onto the negatively charged surfaces of clay minerals.
The responses analyzed were the yield and adsorption of methylene blue. They were related to calcination temperature and time by a second-order polynomial model given in the following equation: