methylsulfonyl

methylsulfonyl

[¦meth·əl ′səl·fə‚nil]
(organic chemistry)
A functional group with the formula CH3SO2‒. Also known as mesyl.
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References in periodicals archive ?
Bobalek, Antimicrobial Performance of Tri-and Tetrachloro-4 (methylsulfonyl) Pyridines as Industial Preservatives.
Methylsulfonyl metabolites of PCBs and DDE in human milk in Sweden, 1972-1992.
[Et.sub.3]N (1.33 ml, 9.5 mmol) and methylsulfonyl chloride (MsCl) (1.15 g, 10 mmol) were added to a solution of dioxepane 3 (2.12 g, 9.4 mmol) in 20 ml of C[H.sub.2][Cl.sub.2].
The main generated by-products are 4-(methylsulfonyl)-2-nitrobenzoic acid, 1,3-diketo 3-(2-nitro-4-methylsulfonylphenyl)butanoic acid, and 5,7-diketo7-(2-nitro-4-methylsulfonylphenyl)-heptanoic acid (Figures 8 and 9).
The synthetic compounds derived from 6-MITC include 6-(methylsulfenyl)hexyl isothiocyanate (I7447) and 6-(methylsulfonyl)hexyl isothiocyanate (I7557).
++++++++++++ R)-tert-Butyl-3-(methylsulfonyl)pyrrolidine-1-carboxylate (1, Method E) was isolated as pale yellow oil using triethylamine as the base (>99%); [sup.1]H NMR [delta] 5.16 (m, [sup.1]H, diastereotopic ring 3-CH); 3.30-3.58 (m, 4H, ring 2 and 5-C[H.sub.2]); 2.92 (s, 3H, mesylate C[H.sub.3]); 1.96-2.15 (m, 2H, ring 4-C[H.sub.2]), 1.32 (s, 9H, t-BOC C[H.sub.3]); [sup.13]C NMR [delta] 28.4, 28.5, 32.0, 32.6, 38.6, 38.7, 43.7, 43.9, 46.2, 51.9, 52.2, 79.8, 80.4, and 154.2; IR (film) 3488, 2979, 1694, 1410, 1366, 1170, 1118, 957, 924, and 900 [cm.sup.?1].
Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin K inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway.
Cyclocondensation of 1-(4-(Methylsulfonyl)phenyl)-2-tosyl-3-(3,4,5-trisubstituted phenyl)prop-2-en-1-ones with 2-Aminothiophenol in Refluxing Toluene Using Catalytic Amounts of Trifluoroacetic Acid.
Abbreviations used: EDTA, ethylenediamine tetraacetate; PAGE, polyacrylamide gel, electrophoresis; PMSF, phenyl- methylsulfonyl fluoride; SDS, sodium dodecyl sulphate
2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N -(methylsulfonyl)acetamide (NS-304), an orally available and longacting prostacyclin receptor agonist prodrug.
Distribution of PCB congeners, DDE, hexachlorobenzene, and methylsulfonyl metabolites of PCB and DDE among various fractions of human blood plasma.