Methyltransferases

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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Methyltransferases

 

(also transmethylases), enzymes of the class of transferases; they catalyze transmethylation of methyl groups.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation.
(8-13) The DNA methyltransferase 3-like (DNMT3L) gene is a member of the DNA methyltransferase 3 (DNMT3) gene family (14) and regulates DNA methylation by interacting with the de novo methyltransferases DNA methyltransferase 3A (DNMT3A) and DNA methyltransferase 3B (DNMT3B).
When cancer cells in the culture dish are treated with CP-4200, the amount of methyltransferase molecules in the interior of the cells is reduced.
Background & objectives: Mercaptopurine, azathioprine, and thioguanine, used as antineoplastic agents and immunosuppressants are catabolized by thiopurine methyltransferase (TPMT) enzyme, which exhibits genetic polymorphism.
Approximately 11% of the population is partially or completely deficient in the enzyme thiopurine methyltransferase, which is involved in the metabolism of azathiowine.
For example, in snapdragons, one particular methyltransferase enzyme adds a methyl group (a central carbon hub bonded to three hydrogen atoms) to benzoic acid, producing methyl benzoate.
The gene, Brown midrib (Bmr), encodes caffeic acid methyltransferase (COMT), a lignin-producing enzyme.
SEATTLE -- A one-time measurement of thiopurine methyltransferase enzyme activity is worthwhile prior to prescribing azathioprine or 6-mercaptopurine for inflammatory bowel disease, Dr.
The objective is to start the clinical program in patients with serious chest infections in 2002; -- a research collaboration with Serono SA (Geneva, Switzerland) to identify new treatments for serious inflammatory diseases, particularly multiple sclerosis; and -- an exclusive option to take up European development and commercialization rights over MethylGene's cancer research program in small molecule inhibitors of DNA methyltransferase.
(10.) Schutz, E, Gummert, J, Mohr, F, Oellerich, M: Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient.
The system is based on CRISPR-dCas9 fused with the catalytic domain of DNA methyltransferase 3A (DNMT3A), an enzyme that is responsible for DNA methylation.
In January 2018, Gotham and ZoBio initiated a collaboration to develop small-molecule inhibitors of the "writer" protein complex METTL3/METTL14, a SAM-dependent methyltransferase that modifies mRNA encoded adenosine in the messenger RNA to m6A and thereby regulates protein expression.