Effects of cadmium on DNA-(Cytosine-5) methyltransferase
activity and DNA methylation status during cadmium-induced cellular transformation.
(8-13) The DNA methyltransferase
3-like (DNMT3L) gene is a member of the DNA methyltransferase
3 (DNMT3) gene family (14) and regulates DNA methylation by interacting with the de novo methyltransferases
3A (DNMT3A) and DNA methyltransferase
When cancer cells in the culture dish are treated with CP-4200, the amount of methyltransferase
molecules in the interior of the cells is reduced.
Background & objectives: Mercaptopurine, azathioprine, and thioguanine, used as antineoplastic agents and immunosuppressants are catabolized by thiopurine methyltransferase
(TPMT) enzyme, which exhibits genetic polymorphism.
Approximately 11% of the population is partially or completely deficient in the enzyme thiopurine methyltransferase
, which is involved in the metabolism of azathiowine.
For example, in snapdragons, one particular methyltransferase
enzyme adds a methyl group (a central carbon hub bonded to three hydrogen atoms) to benzoic acid, producing methyl benzoate.
The gene, Brown midrib (Bmr), encodes caffeic acid methyltransferase
(COMT), a lignin-producing enzyme.
SEATTLE -- A one-time measurement of thiopurine methyltransferase
enzyme activity is worthwhile prior to prescribing azathioprine or 6-mercaptopurine for inflammatory bowel disease, Dr.
The objective is to start the clinical program in patients with serious chest infections in 2002; -- a research collaboration with Serono SA (Geneva, Switzerland) to identify new treatments for serious inflammatory diseases, particularly multiple sclerosis; and -- an exclusive option to take up European development and commercialization rights over MethylGene's cancer research program in small molecule inhibitors of DNA methyltransferase
(10.) Schutz, E, Gummert, J, Mohr, F, Oellerich, M: Azathioprine-induced myelosuppression in thiopurine methyltransferase
deficient heart transplant recipient.
The system is based on CRISPR-dCas9 fused with the catalytic domain of DNA methyltransferase
3A (DNMT3A), an enzyme that is responsible for DNA methylation.
In January 2018, Gotham and ZoBio initiated a collaboration to develop small-molecule inhibitors of the "writer" protein complex METTL3/METTL14, a SAM-dependent methyltransferase
that modifies mRNA encoded adenosine in the messenger RNA to m6A and thereby regulates protein expression.