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(cell and molecular biology)
A submicroscopic structural unit of protoplasm built up from polymeric molecules.
(physical chemistry)
A colloidal aggregate of a unique number (between 50 and 100) of amphipathic molecules, which occurs at a well-defined concentration known as the critical micelle concentration.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a particle of the disperse phase of a sol, that is, of a highly disperse colloidal system with a liquid dispersion medium.

Micelles consist of nuclei of crystalline or amorphous structure and of a surface layer containing solvated molecules of the liquid medium. The surface layer of a micelle of a lyophilic sol is formed of adsorbed molecules or ions of a stabilizer. In the case of lyophobic hydrosols stabilized by electrolytes, the nucleus of the micelle is surrounded by two layers of oppositely charged ions (the electric double layer). There is an equal number of positive and negative charges in the electric double layer; the micelle as a whole is therefore electrically neutral.

The ions of the adsorption layer are located directly on the surface of the nucleus. All ions of one of the signs and some of those of the opposite sign (counterions) are part of this layer. The remainder of the counterions form the diffuse layer, which surrounds the micelle as an ionic cloud whose density decreases with increasing distance from the nucleus. The diffuse layer hinders the approach and aggregation (cohesion) of particles in Brownian motion.

In lyophilic sols and colloidal dispersions of the soap hydrosol type (for example, of sodium oleate or potassium lauryl sulfate), the micelles are molecular aggregates. In each molecule a long hydrocarbon (hydrophobic) chain is bound to a polar (hydrophilic) group. In forming the micelle, dozens or even hundreds of molecules aggregate, so that the hydrophobic radicals form the nucleus (inner region) and the hydrophilic groups form the surface layer. If the dispersion medium is an organic liquid, the orientation of the molecules in the micelle may be reversed. The polar groups concentrate in the nucleus, and the hydrophobic radicals are directed toward the external phase.

The simplest structural types of micelles may be diagramed with the micelle-forming molecule represented as a wavy line (hydrophobic chain) with a small circle (hydrophilic group) at the end (see Figure 1).

Figure 1. Basic micelle types

Micelle structures (1) and (2) represent hydrophilic sols; types (3) and (4), organophilic sols. Upon dilution of the system below the critical micelle-formation concentration, spherical micelles (1) and (3) decompose reversibly into separate molecules or dimers. At higher concentrations, they are converted into lamellar micelles, represented by types (2) and (4); these may interact to form a structural gel network within the system.

The detergent action of aqueous solutions (more precisely, of colloidal dispersions) of soaps, as well as certain phenomena in biological systems and technological processes, are explained by the presence of micelles.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Torchilin, "Lipid-core micelles for targeted drug delivery," Current Drug Delivery, vol.
Ma et al., "Amphiphilic block copolymers-based mixed micelles for noninvasive drug delivery," Drug Delivery, vol.
Since jackfruit seeds are not employed in food industries and since there is a lack of studies on protein extraction from jackfruit seeds by reverse micelles, current research develops an alternative method for protein extraction from jackfruit seed flour using reverse micelles, with sodium dodecyl sulphate (SDS) as surfactant and butanol as organic solvent.
Water insoluble hydrophobic drugs can be encapsulated in amphiphilic PEG-PLA micelles either by physical entrapment method or by covalent chemical conjugation techniques [19].
The micelles with the minute balls of cleansing oil is considered hydrating to the skin.
TX 100 was chosen as surfactant to form micelles. TX 100 is a nonionic surfactant that forms micelles at very low concentration (cmc-critical micelle concentration of 0.24 mM in water) [22], AOT was chosen as surfactant to form reverse micelles.
The association of milk protein composition with CN micelles, based on the least square means for each class, is presented in Table 1.
Heat-induced gelation of casein micelles in aqueous suspensions at different pH.
Chemists and chemical engineers in pharmaceuticals and petroleum summarize the published research on aqueous systems and ionic surfactants, which started with the idea of using reverse micelles as separation agents.
In lower concentrations, frequently, it is observed the formation of micelles, while in higher concentrations can occur one liquid-crystalline phase [4].
noted the cytotoxicity of triptolide and triptolide loaded polymeric micelles against HT29 human adenocarcinoma cells.14 Triptolide is extracted from the Chinese herb having anti-cancer activities Tripterygium wilfordii.