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Related to Microglia: Astrocytes, Oligodendrocytes


Small neuroglia cells of the central nervous system having long processes and exhibiting ameboid and phagocytic activity under certain pathologic conditions.



mesoglia, small rounded cells in the central nervous system.

Microglia develop from cells of connective tissue and constitute about 10 percent of the total number of cells of the neuroglia. Each microglial cell is connected by branching processes with the neuron-neuroglia system and the brain capillaries. The number and size of the microglial cells increase with infections, intoxications, or brain edema. The cells perform a phagocytic role, removing necrotic sections of nerve tissue.

References in periodicals archive ?
These promote the formation of the NLRP3 inflammasome within activated microglia.
Ikezu's lab has extensive experience in the cell biology of microglia, and has studied how the innate aspect of the central nervous system influences the pathology and progression of neurodegenerative disease.
Two-way ANOVA combined with LSD was used to compare the activation of microglia after drug injection.
However, research into the role of human microglia in these disorders has long been hampered by the inability to obtain them from the human nervous system.
It is thought that microglia derive from primitive macrophages in the yolk sac.
The microglia in the brain were deactivated in brains of these animals.
LNE increased the expression of phosphorylated (p)-extracellular signal-regulated kinase (ERK), whereas p-p38 and p- janus kinase (JNK) expression was significantly decreased in activated microglia.
In the first years of her career in brain research, Beth Stevens thought of microglia with annoyance if she thought of them at all.
Activation of microglia, the intrinsic macrophages in the central nervous system (CNS) [1], is a characteristic feature of neurodegenerative diseases.
Microglia activation plays both beneficial and detrimental actions following experimental stroke [5,10,11].
It is based on the firm's prior research of neurodegenerative disease mechanisms, where it showed in preclinical models that semaphorin 4D (SEMA4D) triggers activation of both microglia and astrocytes, the innate inflammatory cells of the central nervous system.