The expressions of pro-inflammation genes of BV-2 microglia cells
, including tumor necrosis factor-a (TNF)-a, IL-1[sz], and inducible nitric oxide synthase (iNOS), were detected by quantitative real-time PCR.
Inflammation and ischaemia--role of microglia cells
This year, Francis Lau, a molecular biologist in the Neuroscience Laboratory, published a study that investigated whether blueberry extracts could have a preventive effect on inflammatory signals coming from activated microglia cells
The researchers found that during the first week of stress exposure, microglia cells
undergo a phase of proliferation and activation, reflected by increased size and production of specific inflammatory molecules, after which some microglia begin to die.
Upon examining the rat brains eight weeks post-trauma, the researchers found "a significant up-regulation of activated microglia cells
, not only in the area of direct trauma, but also in adjacent as well as distant areas.
miniatusdownregulates LPS-induced production of NO, PGE2, and TNF-[alpha] in BV2 microglia cells
via suppression of the NF-[kappa]B pathway.
Scientists from the National Brain Research Centre, Manesar, India, used lipopolysaccharide (LPS), a molecule present on the surface of bacteria, to stimulate an immune response from microglia cells
The findings show that the cells, known as pericytes, drop out from the blood vessel, proliferate and migrate to the damaged brain area where they are converted into microglia cells
, the brain's inflammatory cells.
The CD45 molecule is a receptor on the surface of the brain's microglia cells
, cells that support the brain's neurons and also participate in brain immune responses.