micropinocytosis


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micropinocytosis

[¦mī·krō‚pin·ə·sī′tō·səs]
(cell and molecular biology)
A mechanism of endocytosis in which fluid droplets are internalized by indentations (caveolae) on the surface membrane which pinch off as tiny internal vesicles (micropinosomes).
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This theory originated from studies demonstrating that LDLs modified by endothelial cells, transformation entailing an oxidation process [20], could be internalized and accumulated avidly by macrophages [21,22], leading to foam cell formation, although these cells could also be generated from macrophages internalizing native LDLs from the medium through micropinocytosis [23], or by uptake of aggregated LDLs or LDL immune complexes.