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(cell and molecular biology)
A fragment of the endoplasmic reticulum.
A minute granule of protoplasm.



a fragment in the endoplasmic network (bubbles about 1,000 angstroms diameter), formed when cells are destroyed during the homogenization of animal and plant tissues. The microsome fraction of the homogenate is isolated by differential centrifugation. There are two types of microsomes: smooth-surfaced and rough-surfaced (as a result of the distribution of ribosomes on the latter). Before the technique of separating cellular homogenates was perfected, the microsome fraction also included mitochondria.

References in periodicals archive ?
Gregg, "Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles," Trends in Cell Biology, vol.
Garden cress ethanolic extract significantly inhibited the activity of hepatic microsomal enzymes CYP2D6 and CYP3A4, which was represented by decreased level of metabolites DOR and 3-MM in in vitro experiments.
Stearoyl-CoA desaturase is a microsomal oxidase system required for biosynthesis of oleic acid.
Newsom et al., "Regulation of human microsomal prostaglandin E synthase-1 by IL-1[beta] requires a distal enhancer element with a unique role for C/EBP[beta]," Biochemical Journal, vol.
Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways.
Five (11%) patients showed fluctuating follicle stimulating hormone levels and 6(13%) had detected thyroid microsomal antibodies.
[5] Hiroshi A, Toshlharu H, Masahiro H, Shoji A., 1987, An alteration in liver microsomal memberane of the rat following paracetamol overdose, J pharm pharmacol., 39:1047-9.
La determinacion de la actividad enzimatica de los microsomas se realizo en tubos de microcentrifuga de 1.5 mL que contenian glucosa 6-fosfato 5 mM, NADP+ 0.5 mM, glucosa 6-fosfato deshidrogenasa 0.5 UI, 2 [micron]L de sustrato (AFB1) en DMSO equivalente al 0.8% del solvente de incubacion (18), 100 [micron]g de proteina microsomal y buffer de incubacion (buffer fosfato 50 mM pH 7.4, MgCl 5mM, EDTA 0.5mM) hasta un volumen de 250 [micron]L.
The patient was diagnosed to have GCH-AIHA condition, and anti-nuclear and anti-liver kidney microsomal antibodies were found to be negative.
[2] Human genes: BRCA1, breast cancer 1, early onset; BRCA2, breast cancer 2, early onset; MGST3, microsomal glutathione S-transferase 3; GBP1, guanylate binding protein 1, interferon-inducible, 67kDa; MTAP, methylthioadenosine phosphorylase; GGH, gamma-glutamyl hydrolase (conjugase, folylpolygamma-glutamyl hydrolase); MADCAM1, mucosal vascular addressin cell adhesion molecule 1; POSTN, periostin, osteoblast specific factor; PMS1, PMS1 postmeiotic segregation increased 1 (S.
The mechanism by which phenytoin and other AEDs cause bone loss is not entirely clear, but relates to hepatic microsomal induction of enzymes that enhance the metabolism of 25-hydroxyvitamin D to inactive metabolites.

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