microtubule-associated protein


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microtubule-associated protein

[¦mī·krō‚tüb·yül a¦sō·sē‚ād·ed ′prō‚tēn]
(cell and molecular biology)
A protein that enhances the rate and extent of the polymerization of intracellular microtubules or that modifies their properties once formed. Abbreviated MAP.
References in periodicals archive ?
LC3A, also called MAP1LC3A (microtubule-associated proteins 1A/1B light chain 3A), one of the mammalian homologues of yeast autophagy-related gene 8 (Atg8), was found to be expressed in 27 out of 88 (30.7%) samples.
Cambiazo, "Role of microtubule-associated proteins in the control of microtubule assembly," Physiological Reviews, vol.
SCIR: spinal cord ischemia reperfusion; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; LC3: microtubule-associated protein 1 light chain 3; I/R: ischemia reperfusion; 3-MA: 3-methyladenine; BBB: Basso, Beattie, and Bresnahan; ANOVA: analysis of variance.
Abbreviations: hepatocellular carcinoma, HCC; dietary supplement, DS; focal adhesion kinase, FAK; transforming growth factor beta, TGF-[beta]; nuclear factor kappa-light-chain-enhancer of activated B cells, NF-[kappa]B; activator protein 1, AP-1; 3-(4,5-dimethyithiazol-2-yl)-2,5-diphenyltetrazolium bromide, MTF; bafilomycin A1, BafA1; 4'-6-diamidino-2-phenylindole, DAPI; Dulbecco's modified Eagle's medium, DMEM; fetal bovine serum, FBS; polyvinylidene difluoride, PVDF; acidic vesicular organelles, AVOs; poly (ADP-ribose) polymerase, PARP; microtubule-associated protein 1A/1B-light chain 3, LC3; mitogen-activated protein kinases, MAPK.
Kirschner, "Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin," Journal of Molecular Biology, vol.
Growing evidence indicates that the cytoskeleton, a structural system including microtubules and microtubule-associated proteins (MAPs), may play an important role in stress-induced impairments of neuronal structural plasticity (10).
There is further evidence of a role for p38[delta] MAPK in cytoskeleton regulation as the microtubule-associated protein stathmin has also been characterised as a good p38[delta] MAPK substrate in vitro and in transfected cells exposed to osmotic shock [50].
The microtubule assembly conditions without and with XMAP215 are assumed to be comparable to the previously described conditions for microtubule assembly without and with microtubule-associated proteins, respectively.
The sections were stained for S-100 protein, glial fibrillary acidic protein (GFAP), cytokeratin, and microtubule-associated protein. Stains were positive for S-100 protein (figure 2, B) and GFAP (figure 2, C).
Goedert, "Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK)," Journal of Neurochemistry, vol.90, no.2, pp.352-358, 2004.
A variety of hypotheses have been proposed for explaining the causes of AD, such as cholinergic hypothesis, amyloid b-proteins hypothesis, and microtubule-associated protein tau hypothesis etc.

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