microtubule-associated protein

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microtubule-associated protein

[¦mī·krō‚tüb·yül a¦sō·sē‚ād·ed ′prō‚tēn]
(cell and molecular biology)
A protein that enhances the rate and extent of the polymerization of intracellular microtubules or that modifies their properties once formed. Abbreviated MAP.
References in periodicals archive ?
LC3A, also called MAP1LC3A (microtubule-associated proteins 1A/1B light chain 3A), one of the mammalian homologues of yeast autophagy-related gene 8 (Atg8), was found to be expressed in 27 out of 88 (30.7%) samples.
Cambiazo, "Role of microtubule-associated proteins in the control of microtubule assembly," Physiological Reviews, vol.
Genetic and nongenetic alterations have been suspected to be involved in the development of drug resistance in previous studies.12,13 Although this resistance appears to be multifactorial; defects in tubulin and microtubule-associated proteins (MAPs), dysregulated cell cycle and apoptotic signaling pathways are among the factors thought to be responsible for taxane resistance.14 Researchers have demonstrated the relationship between taxane resistance and the overexpression of MAPs, tau protein, STHMN1 and OPN with in vitro and in vivo studies.4,6 We investigated whether STHMN1 and OPN expressions could be predictive markers for cancer metastasis and resistance to TBR in mCRPC.
(2013) Spatial organization of xylem cell walls by ROP GTPases and microtubule-associated proteins. Curr.
Microtubule-associated proteins as targets in cancer chemotherapy.
The granule maturation process as described for beta cells [28, 29] and intracellular movement of insulin/transmitter containing vesicles depends on a functioning microtubular machinery together with motor proteins and microtubule-associated proteins such as the MAPT [30].
Growing evidence indicates that the cytoskeleton, a structural system including microtubules and microtubule-associated proteins (MAPs), may play an important role in stress-induced impairments of neuronal structural plasticity (10).
The microtubule assembly conditions without and with XMAP215 are assumed to be comparable to the previously described conditions for microtubule assembly without and with microtubule-associated proteins, respectively.
Mandelkow, "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption," Cell, vol.89, no.2, pp.297-308, 1997.
PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles.
Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia, Proc.

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