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A discrete nodular lesion of inflammatory tissue in which granulation is significant.



a focal growth of inflammatory origin in the cells of young connective tissue in the form of a small node.

Granuloma develops in connection with various (most often infectious) processes (tuberculosis, syphilis, leprosy, brucellosis, tularemia, actinomycosis), with collagenic diseases (such as rheumatism), and at the sites of entry of foreign bodies. Certain granulomas have more specific names, such as the tubercle in tuberculosis and the gumma in syphilis.

References in periodicals archive ?
In 1995, Sevinsky et al described a case of total nasal septal destruction and a necrotic ulcer on the philtrum that mimicked a midline granuloma.
It is now recognized that the vast majority of cases of lethal midline granuloma represent nasal T-cell lymphomas.
Because malignant lymphomas are associated with surface crusting, widespread necrosis, and inflammation, they were once considered to be inflammatory lesions, known as lethal midline granulomas or nonhealing granulomas.