mifepristone


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mifepristone

an antiprogestogenic steroid, used in the medical termination of pregnancy. Formula: C29H35NO2
References in periodicals archive ?
Women have been known to pick up misoprostol--which can be used alone to abort, though not as successfully--on the black market at places like border town flea markets [1] and have been able to order packets of foreign manufactured mifepristone and misoprostol from the internet [2].
Some studies have found that mifepristone affects follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-both secreted by the pituitary, subsequently causing a series of reproductive endocrine changes-a side effect likely to contribute to pregnancy failure in females in a short time after discontinuing mifepristone treatment (Tamura et al., 2009; Weisberg et al., 2011).
Despite its extensive safety record, mifepristone is subject to an FDA-imposed Risk Evaluation and Mitigation Strategy (REMS) that limits its distribution to registered providers in clinics, hospitals and medical offices.
After randomization, 149 participants received 200 mg of oral mifepristone (Mifeprex), with 800 meg misoprostol administered approximately 24 hours later.
Findings from a trial show that while the standard drug regimen using misoprostol on its own frequently fails to complete the miscarriage, a combination of misoprostol and the drug mifepristone works better.During miscarriage, if the body does not expel the pregnancy tissue on its own, which is the final part of a miscarriage, women need to undergo a surgical procedure or take the drug misoprostol.
Schreiber, M.D., M.P.H., from the University of Pennsylvania in Philadelphia, and colleagues randomized 300 women who had an anembryonic gestation or in whom embryonic or fetal death was confirmed to receive pretreatment with mifepristone, administered orally followed by misoprostol administered vaginally, or to misoprostol alone administered vaginally.
The Sample Size and Allocation of Study Subjects were taken for Convenience and was divided into Three Groups A, B and C Group A: Subjects receiving 600 mg oral mifepristone and 200 [micro]g vaginal misoprostol.
According to the labels of mifepristone and misoprostol used in Bangladesh, these products are indicated as a "medical alternative to surgical termination of intrauterine pregnancy." 2 When a search is made for "termination of pregnancy" in the thesaurus vocabulary for PubMed, the retrieved term is "abortion, induced." Also, when citing mifepristone, Planned Parenthood and the Guttmacher Institute use the term "medication abortion" in their websites.
Utah's law, meanwhile, requires that physicians explain "the options and consequences of aborting a medication-induced abortion" and inform women that mifepristone alone is not always effective in ending a pregnancy.
Medical therapy with mifepristone (Korlym[R], Corcept Therapeutics, Menlo Park, CA) was initiated at 300 mg per day and increased to 900 mg during the 34 weeks of treatment.
The treatment group orally took mifepristone tablets (12.5 mg/time, once/day), and the dosage and administration of gestrinone capsules were the same as those of the control group.
It was early morning on July 19,1996, and four NWHN colleagues and I were on the way to attend the FDA Advisory Committee meeting about mifepristone (known as "RU 486" or the "French abortion pill").