receptor is a receptor for steroid hormones that control the blood's electrolyte balance.
Treatment requires replacing corticosteroids and mineralocorticoids
to cover for the hormones the adrenal gland is not producing.
It is important to note that some dogs who initially present with atypical Addison's will progress to the more typical disease, eventually requiring the mineralocorticoid
supplementation, as well.
Changes in glucocorticoid and mineralocorticoid
hormone levels due to compensation for ileostomy losses.
antagonists for recalcitrant central serous chorioretinopathy.
In this study, four patients (66.7%) had hypertension and three had hypokalemia (50%) while others had not developed the symptoms of mineralocorticoid
excess at presentation.
The most common causes of endocrine hypertension are excess production of mineralocorticoids
(primary hyperaldosteronism), catecholamines (pheochromocytoma), thyroid hormone, and glucocorticoids (Cushing syndrome) (4).
Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition with an incidence of approximately 1 in 12,500 Caucasian births.1 It is caused by the mutations of genes for enzymes mediating the biochemical steps of production of mineralocorticoids
, glucocorticoids or sex steroids from cholesterol by the adrenal glands (steroidogenesis).2 Most of these conditions involve excessive or deficient production of sex steroids and can alter development of primary or secondary sex characteristics in some affected infants, children or adults.3 CAH is characterized by deficiency of one of the enzymes required to make cortisol - required for stress response, maintenance of blood pressure; aldosterone - required for salt retention; or androgens - for virilization of the fetus (rare form).
The combination of alkalosis hypokalaemia and hypertension suggests increased mineralocorticoid
activity leading to increased renal tubular Na+ reabsorption along with increased k+ and H+ excretion.
Funder, "Affinity of liquorice derivatives for mineralocorticoid
and glucocorticoid receptors," Clinical Endocrinology, vol.
In primary adrenal insufficiency, maintenance therapy requires both glucocorticoids and mineralocorticoid
This often leads to an increase of mineralocorticoid