The primer ser for each gene was followed: histone deacetylase 9 (HDAC9) forward, 5'-GCAAGAGGAGACAGAGACCG-3'; HDAC9 reverse, 5' - ACTTG G C ACTTCAC AAG G CT- 3'; minichromosome
maintenance deficient 3 associated protein (MCM3AP) forward, 5'-CGCTTCCTCTGGTGGTTCTT-3'; MCM3AP reverse, 5'CTGCACTGCTTGCAAAACCT-3'; GAPDH forward, 5'-TCACCCACACTGTGCCCATCTATGA-3'; GAPDH reverse, 5'-GAGGAAGAGGATGCGGCAGTGG-3'.
Markers that have been studied in the literature and that are not considered useful in the diagnosis of mesothelioma versus mesothelial hyperplasia include minichromosome
maintenance 2 protein, telomerase transcriptase expression (which needs to be studied further), Ki-67, transforming growth factor, epidermal growth factor receptor, Bcl-2, and argyrophilic nucleolar organizer region.
In prostate cancer, results of a recently reported study demonstrated that binding of the vitamin D (1,25-dihydroxyvitamin D3) receptor [encoded by the vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene] to the MCM7 promoter [encoded by minichromosome
maintenance complex component 7 (MCM7)] resulted in acetylation of histone H3 lysine 9 and, subsequently, enhanced transcription of miR-106b, which is located in an intron of the MCM7 gene (25).
Proteins encoded by the minichromosome
maintenance (MCM) genes have also been proposed as useful markers of proliferation; with high levels of gene expression indicating poor prognosis (20).
The best studied example of colonocyte testing in feces is the minichromosome
maintenance proteins (MCM).
the Company's Chief Scientific Officer, in which the author describes an emerging class of markers, the Minichromosome
Maintenance protein family of DNA licensing factors (MCM-2, MCM-6, MCM-7) and Topoisomerase II alpha, that show promise for the specific detection of CIN2+ cervical conditions using simple antibody-based immunochemistry formats.
Justin Davies described a novel test that utilizes antibodies to detect minichromosome
maintenance protein 2 (Mcm2) in colonocytes exfoliated onto the surface of stool.
Maintenance Complex (MCM) proteins are highly expressed in malignant cells and are promising targets for anticancer drugs.
538 MCM7 Minichromosome
Component of maintenance complex putative replicative component 7 helicase -0.
1 interacting protein 2 (PAIP2) Minichromosome
maintenance complex NM_001006527.
The ProExC antibody, which targets the virally upregulated proteins minichromosome
maintenance protein 2 and topoisomerase II-[alpha], can also be used as an aid in the identification of HPV-related dysplasia in the uterine cervix.
Use of linkage disequilibrium and haplotype analysis of affected Finnish families revealed a defined DNA transition (-13910T/C) proximal to the LCT gene in intron 13 of the adjacent minichromosome
maintenance type 6 gene (MCM6), which is associated with verified lactase nonpersistence and reduced bone mineral density predisposing for bone fractures (1, 2).