minichromosome


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minichromosome

[‚min·ē′krō·mə‚sōm]
(cell and molecular biology)
A eukaryotic chromosome reduced in size by deletion of a segment of deoxyribonucleic acid.
(virology)
Viral deoxyribonucleic acid combined with histone to form a chromatin-like structure.
References in periodicals archive ?
This research focused on a ring-shaped enzyme called the minichromosome maintenance or MCM complex that plays a central role.
Developed and perfected at its Sunderland headquarters, the diagnostics kit is based on the detection of minichromosome maintenance proteins (MCM5) in the urine as an indication of the presence of bladder cancer.
qRT-PCR analysis confirmed that the mRNA levels of cyclin family members ( ccna1 , ccnb1 , ccnd1 , and cdk1 ), minichromosome maintenance proteins ( cdc45 , mcm2 , mcm3 , mcm4 , mcm5 , mcm6 , and mcm7 ), and proliferation cell nuclear antigen ( PCNA ) were significantly upregulated in ATF3-overexpressing CFs [Figure 3]a.
After entry into the cell, the first event in HBV DNA replication is conversion of the relaxed circular DNA genome into a covalently closed circular DNA (cccDNA) minichromosome in the nucleus of hepatocytes (Fig.
[75] Human Genes: LCT, lactase; MCM6, minichromosome maintenance complex component 6.
ProExC, a novel immunohistochemical cocktail--composed of topoisomerase II a (TOP2A) and minichromosome maintenance protein 2 (MCM2) antibodies--has also been recently suggested to be a useful marker of high-grade dysplasia (25,26): strong nuclear staining in more than half of the epithelial thickness showed 90% sensitivity and 79% positive predictive value for HSIL.
Three types of B chromosomes were identified: a subtelocentric B (BST), a metacentric B chromosome (BT) and a small B minichromosome (BM).
The marker minichromosome maintenance protein 2 (MCM2) has been used in cancer research as a marker to identify dividing cells in situ and is able to detect cells throughout the cell cycle starting in early G1 phase.
Guerrieri et al., "IFN-[alpha] inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome," The Journal of Clinical Investigation, vol.
Allweiss, F Guerrieri et al., "IFN-[alpha] inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome," The Journal of Clinical Investigation, vol.
Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications.
The primer ser for each gene was followed: histone deacetylase 9 (HDAC9) forward, 5'-GCAAGAGGAGACAGAGACCG-3'; HDAC9 reverse, 5' - ACTTG G C ACTTCAC AAG G CT- 3'; minichromosome maintenance deficient 3 associated protein (MCM3AP) forward, 5'-CGCTTCCTCTGGTGGTTCTT-3'; MCM3AP reverse, 5'CTGCACTGCTTGCAAAACCT-3'; GAPDH forward, 5'-TCACCCACACTGTGCCCATCTATGA-3'; GAPDH reverse, 5'-GAGGAAGAGGATGCGGCAGTGG-3'.

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