mitogen-activated protein kinases

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Related to Mitogen-activated protein kinase: MAP kinase, MAPK

mitogen-activated protein kinases

[‚mīd·ə·jən ¦ak·tə‚vād·əd ¦prō‚tēn ′kī‚nās·əs]
(cell and molecular biology)
A large kinase network in which upstream kinases activate downstream kinases that, in response to phosphorylation, translocate to the nucleus and activate transcription factors. Abbreviated MAPKs.
References in periodicals archive ?
Lee, "Big mitogen-activated protein kinase 1/extracellular signalregulated kinase 5 signaling pathway is essential for tumorassociated angiogenesis," Cancer Research, vol.
Induction of mitogen-activated protein kinases is proportional to the amount of pressure overload.
Differential contribution of three mitogen-activated protein kinases to PDGF-BB-induced mesangial cell proliferation and gene expression.
Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer.
Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation.
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.
Genomewide RNAi screen identifies protein kinase Cb and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis.
Yao et al., "Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1," Journal of Clinical Endocrinology and Metabolism, vol.
The mitogen-activated protein kinase (MAPK) cascades, consisting of the extracellular signal-related kinases (ERK1/2), the c-Jun N-terminal kinases (JNK), the p38 kinase (p38), and the big MAP kinase 1 (BMK1/ERK5) pathway [47], are major intracellular signal transduction pathways that play an important role in various cellular processes such as cell growth, differentiation, development, cell cycle, survival, and cell death [48].
Salh, "The p38 mitogen-activated protein kinase regulates interleukin-1[beta]-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells," Immunology, vol.
It has been proposed that GRP stimulation results in increased release of epidermal growth factor receptor (EGFR) proligands, which is metalloprotease dependent and results in activation of EGFR and mitogen-activated protein kinase downstream pathways (13, 14) (Figure 1).
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