Clinical trial design principles and endpoint definitions for transcatheter mitral valve
repair and replacement: Part 1: clinical trial design principles - a consensus document from the Mitral Valve
Academic Research Consortium.
The global mitral valve
stenosis market has been segmented into treatment, diagnostic tests, and end user.
When the two leaflets of a mitral valve
fail to close tightly between beats ("coapt"), blood leaks backwards, and the body does not receive sufficient oxygen.
The patient recently began experiencing symptoms of mitral valve
Mean mitral valve
area of the patients, prior to the procedure was 0.81 +- 0.1cm2 and post PTMC, mean mitral valve
area became 1.52 +- 0.1cm2.
First order anterior mitral valve
leaflet chordae prevent leaflet prolapse and insufficiency.
Results from the Cleveland Clinic show an operative mortality of 2.3% in 44 patients with severe MR and severe LV dysfunction (EF < 35%) that underwent isolated mitral valve
repair (MVR) or replacement.
The lesions of the mitral valve
observed during the systematic intraoperative assessment are summarized in [Supplementary Table 2 [SUPPORTING:2]] and [Supplementary Table 3 [SUPPORTING:3]].
Prior to this clinical trial, doctors looked to open-heart surgery to repair or replace the mitral valve
as one way to alleviate the mitral regurgitation, according to Northwell Health.
* Valve repair is a good option to treat mitral valve
regurgitation due to valve prolapse.
Conclusion: Percutaneous mitral balloon valvotomy was a safe procedure in patients with favorable Wilkin's score in terms of improvement in mitral valve
area, left atrial volume, pulmonary artery pressure and improvement in mitral valve
The prevalence of mitral valve
prolapse increases linearly with age, being more commonly associated with the female sex and with mitral regurgitation (Schoenhoff et al 2011; Malev et al 2014).