modifier gene


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Related to modifier gene: recessive epistasis, epistatic

modifier gene

[′mäd·ə‚fī·ər ‚jēn]
(genetics)
A gene that alters the phenotypic expression of a nonallelic gene.
References in periodicals archive ?
In this study, we first showed that human BOP gene might be modifier gene for HCMP The linked rare allele of three SNPs at exon 6 of human BOP gene had significantly relationship with QT dispersion values of HCMP patients.
Therefore, the resistance in SC8021V2 is probably controlled by one major gene and with the possibility of at least one modifier gene.
We also have planned studies to search for modifier genes that modulate the severity of CF lung disease and may have an impact on the severity of other chronic bronchitic airway diseases in humans.
3) research on modifier genes and environmental influences in animal models;
Some fetuses will be lost in utero, others will be protected by modifier genes.
It is not clear if this effect is caused by genes at different loci, different alleles, or modifier genes.
I'm sure we'll learn that there are other, modifier genes involved," he adds.
Identifying modifier genes is important not only to fully assess genetic risk, but also to provide novel targets for therapy; however, identifying modifier genes has proven challenging.
Niles (1980) reported that the increase in the plant hairiness is governed by two major genes and a complex of modifier genes.
Mutations in these genes account for a small proportion of HSCR patients (7%) and have reduced penetrance and various effects on the length of the aganglionosis (1, 2), suggesting that modifier genes influence the penetrance and severity of the phenotype (28, 29).
However, chemicals exert their adverse effects over dose and time, and there are modifier genes in various species or strains that can affect the action of a chemical through metabolism or during some of the basic processes of injury and repair.