Since NV-5138 does not directly modulate
the NMDA receptor pathway, the compound may not have the side effects and abuse potential of the NMDA receptor modulators currently in development.
The company has built an intellectual property portfolio that covers Reglemers, first-in-class molecules that modulate
Our results indicate that waterborne estrogenic chemicals can modulate
brain activity in aquatic vertebrates.
"We have now shown that light also can modulate
conditioned fear responses."
Methods for modulating development of T helper type 1 (Th1) or Th2 subsets in a subject using agents that modulate
transcription factor activity are also disclosed.
For example, a recent investigation based on silencing of 510 genes identified new cellular components that modulate
the apoptotic response to tumor necrosis factor-related apoptosisinducing ligand (TRAIL) (Aza-Blanc et al.
Awnings, velaria, water and planting modulate
the climates of bazaar alleys [p52].
University of California (Oakland, CA) has patented a method using a two-hybrid system to screen for agents that modulate
the ability of a cell to degrade or to accumulate a metabolic product or to selective kill a cell or to selectively express a gene or cDNA in a cell that has a defect in its ability to degrade or to accumulate a metabolic product.
Genetic and environmental interactions modulate
an individual's susceptibility to certain diseases/disorders.
Individual differences in the capacity to modulate
pain centrally have been associated with chronic pain symptoms as well as the onset of chronic pain following surgery (Arendt-Nielsen & Yarnitsky, 2009).