The study, led by researchers at the University of Pennsylvania, identifies a new molecular circuit
that controls longevity in yeast and more complex organisms and suggests a therapeutic intervention that could mimic the lifespan-enhancing effect of caloric restriction, no dietary restrictions necessary.
Thus, Lou and colleagues identified for the first time a molecular circuit
in which NMD acts to drive a normal biological response.
Robert Orchard, another study author, said: "By asking 'how does a bacterial pathogen from outside the cell regulate the host cells' actin dynamics within the cell?', we have uncovered a fundamentally new molecular circuit
involved in mammalian cell polarity and bacterial infection.
Summary: TEHRAN (FNA)- Scientists demonstrated the transduction of optical radiation to electrical current in a molecular circuit
. The system, an array of nano-sized molecules of gold, respond to electromagnetic waves by creating surface plasmons that induce and project electrical current across molecules, similar to that of photovoltaic solar cells.
components are potentially more versatile than existing microelectronics, and may lead to reduced cost and lower power consumption.
Topics include a VHDL core for intrinsic evolution of discrete time filters with signal feedback, non-evolvable indirectly replicating nanorobots with self- assembling parts, complexity metrics for self-monitoring impact sensing networks, and molecular circuit
Iliopoulos and his colleagues found that in mice given a carcinogenic chemical, DEN, liver cancer was initiated by the activation of a molecular circuit
that sets up an inflammatory state in the cells, leading to cancer.
The network describes how genes in the human genome work together in the brain's molecular circuits
. While every cell in the human body contains a complete set of genetic instructions for the entire body, only a portion of these genes are "turned on" in any given cell at any given point in development or everyday life.
The framework allows the description of complex molecular circuits
that have never been previously designed and tested in terms of functionality.
Cell growth and division are regulated by molecular circuits
known as "cell cycle control," a coordinated protein-protein interacting network, that monitor cell proliferative signals, genome integrity, and proper timing of cell cycle transition from four different phases including S phase (DNA synthesis), M (mitosis), and two interphases (G1 and G2) between S and M phases .
Zhangs research focuses on adaptive cellular response to biological stressors and how nonlinear dose response arises from the underlying molecular circuits
Signal transduction pathways respond to different environmental conditions; they are like molecular circuits
that detect and integrate diverse external signals to alter gene transcription.