CRISPR-Cas9 is a
molecular machine first discovered in bacteria that can be programmed to go to an exact place in the genome, where it cuts the DNA.
It's like a
molecular machine that walks along the filaments," she said.
The "base editor" is a
molecular machine that directly converts one building block of DNA into another.
We chose the myosin motor as a model
molecular machine. Myosin is an actin-based motor that converts the chemical energy released from ATP hydrolysis into mechanical energy to generate muscle contraction and other types of cellular motility.
"A new field called nano-medicine is emerging which is the science and technology of diagnosing, treating and preventing disease and traumatic injury, relieving pain and preserving human health using nanocstructured materials and eventually complex
molecular machine systems and nano-robots".
Focusing on the work of Gary Lynch and his research team at the University of California, this book shows how cutting-edge science has revealed the inner workings of the
molecular machine that manufactures our memories, and the discovery of a new class of drugs that not only enhance brain function but offer tantalizing possibilities for curing many neurological diseases.
Ada E Yonath, who shared the 2009 chemistry prize with V Ramakrishnan for discovering ribosome's translation of DNA information into life, also a major target for new antibiotics in medicine, showed it was looking at the hibernating bears and how they packed their ribosomes before preparing for the harsh winter that she got an insight into how this
molecular machine existed beyond environmental conditions.
RNAP functions as a "
molecular machine," in Ebright's words, opening and closing like a hinged crab claw to let DNA in and then hold it tightly.
They recently discovered that the process of storing long-term memories is much more dynamic, involving a miniature
molecular machine that must run constantly to keep memories going.
The laboratory scientist of today can tell you, quite rightly, that current fabrication technology can't make
molecular machine parts out of diamond.
They're working on a transition metal-based chemical catalyst, a sort of reusable
molecular machine that will convert glucose or other carbohydrates into usable starting points for manufacturing chemicals and plastics.
His research interests include: nanomedicine, medical nanorobotics design,
molecular machine systems, diamondoid mechanosynthesis (theory and experimental pathways), molecular assemblers and nanofactories, and self-replication in machine and factory systems.
