molecular mimicry


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molecular mimicry

[mə′lek·yə·lər ′mim·i‚krē]
(immunology)
The sharing, by two organisms closely related ecologically but not phylogenetically, of common macromolecular structures that are not attributable to evolutionary conservation of these structures.
References in periodicals archive ?
Transport of toxic metals by molecular mimicry. Environ Health Perspect.
Root-Bernstein, "Rethinking molecular mimicry in rheumatic heart disease and autoimmune myocarditis: laminin, collagen IV, CAR, and B1AR as initial targets of disease," Frontiers Pediatrics, vol.
Every autoimmune disease seems to have those same components: molecular mimicry between a host tissue and microorganism, with the inflammatory response set off by some sort of immune-stimulating event.
Cross reactive theories such as molecular mimicry, has been gaining strong experimental support.
The protozoa Toxoplasma gondii has also been reported to potentially induce autoimmune thyroid cross-reactivity through molecular mimicry mechanisms [11].
Molecular mimicry as a mechanism of autoimmune disease.
According to one theory, the antigen triggering the reaction is a viral protein with molecular mimicry to a thyroid protein, although clear evidence for a viral etiology is lacking.
Hibbard's expert report concluded she was suffering from "molecular mimicry [which occurs when] a vaccine generates an immune response that attacks the sympathetic nerve fibers ...
The mechanism of bacteria interfering with host TLR signaling by Tcps, by blocking endogenous protein's association, was described as molecular mimicry [12].
The different mechanisms suggested for the role of human cytomegalovirus in diabetogenesis maybe related to (1) molecular mimicry induced by T-cell cross-reactivity between human cytomegalovirus and GAD65 (glutamic acid decarboxylase exists as two isoforms GAD65 and GAD67, a major enzyme required for the production of the gamma amino butyric acid which regulates the glucagon secretion) in pancreatic islet [beta]-cells [102, 103]; (2) the persistence of HCMV specific CD4+ T-cells or a bystander activity [104]; and (3) persistent infection in [beta]-cells [127].
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