To achieve high sensitivity and accuracy, several innovations in molecular recognition
and fluorescence signalling are integrated into the design of these unconventional molecular analytical devices.One of the most important motivations for developing these sensors lies in their potential to diagnose a variety of diseases in their early stages.
Among the topics are the thermodynamic and kinetic basis of liquid chromatography, aptamers as molecular recognition
elements in chromatographic separations, and determining endocrine disrupting chemicals found in environmental samples using gas chromatography and mass spectrometry.
The outstanding researchers in Thatcher's group have used techniques from high level computational methods, through reaction and enzyme kinetics, to binding studies on molecular recognition
. But this research is primarily based upon an ability to synthesize a large variety of novel organic compounds with biological activity.
Our objective is to design a zeolite synthesis methodology that creates pores and cavities in the resulting zeolite that approach a molecular recognition
pattern to catalyze the desired reaction.
Because molecular recognition
is the basis for most biological processes, from ligand-receptor binding to translation and transcription of the genetic code, the value of being able to design biomimetic materials with molecular recognition
properties is evident.
Solvents with ranging chemical properties such as polarity and protic nature were pumped through each MIP column and the non-covalent forces responsible for the molecular recognition
process were investigated.
Metals in biology are extremely important but are also extremely complex to characterize and its role in processes such as protein assembly and molecular recognition
is still poorly understood.
Other topics include NMR techniques for very large proteins and RNAs in solution, water mediation in protein folding and molecular recognition
, and cryo- electron microscopy of spliceosomal components.
This situation has stimulated our efforts to develop numerical tools which can analyze the details of molecular recognition
and catalytic processes in enzymes that are difficult to ascertain via present biophysical and biochemical experimental methods.
On the other hand, it is known that gold(I) compounds can find application in molecular recognition
processes of cations and anions, where the signalling arises from the modulation of aurophilic or chromophore interactions.The project plans the study of several types of alkynyl gold(I) complexes containing coumarins, polyamines and positively charged alkylated ligands, respectively.
The process of molecular recognition
and binding of ligands (atoms, ions and molecules) by proteins with high sensitivity is key to both basic and applied sciences.
If your library already receives Journal of Inclusion Phenomena and Molecular Recognition
in Chemistry, you might wish to alert your librarian that this is a reprint, in order to avoid an unnecessary expenditure.