molecular recognition


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Molecular recognition

The ability of biological and chemical systems to distinguish between molecules and regulate behavior accordingly. How molecules fit together is fundamental in disciplines such as biochemistry, medicinal chemistry, materials science, and separation science. A good deal of effort has been expended in trying to evaluate the underlying inter-molecular forces. The weak forces that act over short distances (hydrogen bonds, van der Waals interactions, and aryl stacking) provide most of the selectivity observed in biological chemistry and permit molecular recognition. The recognition event initiates behavior such as replication in nucleic acids, immune response in antibodies, signal transduction in receptors, and regulation in enzymes. Most studies of recognition in organic chemistry have been inspired by these biological phenomena. It has been the task of bioorganic chemistry to develop systems capable of such complex behavior with molecules that are comprehensible and manageable in size, that is, with model systems. See Antibody, Chemoreception, Enzyme, Nucleic acid, Synaptic transmission

molecular recognition

[mə¦lek·yə·lər ‚rek·ig′nish·ən]
(cell and molecular biology)
The ability of biological and chemical systems to distinguish between molecules and regulate behavior accordingly.
(chemistry)
The (molecular) storage and the (supramolecular) retrieval and processing of molecular structural information and interactions.
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To achieve high sensitivity and accuracy, several innovations in molecular recognition and fluorescence signalling are integrated into the design of these unconventional molecular analytical devices.One of the most important motivations for developing these sensors lies in their potential to diagnose a variety of diseases in their early stages.
Among the topics are the thermodynamic and kinetic basis of liquid chromatography, aptamers as molecular recognition elements in chromatographic separations, and determining endocrine disrupting chemicals found in environmental samples using gas chromatography and mass spectrometry.
The outstanding researchers in Thatcher's group have used techniques from high level computational methods, through reaction and enzyme kinetics, to binding studies on molecular recognition. But this research is primarily based upon an ability to synthesize a large variety of novel organic compounds with biological activity.
Our objective is to design a zeolite synthesis methodology that creates pores and cavities in the resulting zeolite that approach a molecular recognition pattern to catalyze the desired reaction.
Because molecular recognition is the basis for most biological processes, from ligand-receptor binding to translation and transcription of the genetic code, the value of being able to design biomimetic materials with molecular recognition properties is evident.
Solvents with ranging chemical properties such as polarity and protic nature were pumped through each MIP column and the non-covalent forces responsible for the molecular recognition process were investigated.
Metals in biology are extremely important but are also extremely complex to characterize and its role in processes such as protein assembly and molecular recognition is still poorly understood.
Other topics include NMR techniques for very large proteins and RNAs in solution, water mediation in protein folding and molecular recognition, and cryo- electron microscopy of spliceosomal components.
This situation has stimulated our efforts to develop numerical tools which can analyze the details of molecular recognition and catalytic processes in enzymes that are difficult to ascertain via present biophysical and biochemical experimental methods.
On the other hand, it is known that gold(I) compounds can find application in molecular recognition processes of cations and anions, where the signalling arises from the modulation of aurophilic or chromophore interactions.The project plans the study of several types of alkynyl gold(I) complexes containing coumarins, polyamines and positively charged alkylated ligands, respectively.
The process of molecular recognition and binding of ligands (atoms, ions and molecules) by proteins with high sensitivity is key to both basic and applied sciences.
If your library already receives Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, you might wish to alert your librarian that this is a reprint, in order to avoid an unnecessary expenditure.

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