SSRIs thus have a role in both monoamine
and neuroplasticity theories of depression.
May take drooling, anorexia, Eldepryl), several weeks to see hearing loss, itching, Monoamine
Previously proposed mechanisms of the zonisamide-induced increase in dopamine concentration are activation of tyrosine hydroxylase  and inhibition of monoamine
oxidase (MAO)-B [24,25].
There are tons of studies suggesting that depressions are due to monoamine
neurotransmitter changes [16-19]; in addition, many other hormones are also involved, such as sex hormones .
Initiation of an MAOI is always based on whether the patient can reliably follow the basic dietary advice (see "A concise guide to monoamine
inhibitors," CURRENT Psychiatry.
The research on monoamine
oxidases in the authors' laboratories is supported by Fondazione Cariplo (Grant 2014-0672), by the French INSERM (Institut pour la Sante Et la Recherche Medicale) and by a grant from the "Region Midi-Pyrenees."
Pure recombinant human monoamine
oxidases (MAO-A and MAO-B) enzymes overexpressed in baculovirus (Autographa californica) infected insect cells (BTI-TN-5B1-4) were purchased from BD Biosciences, (Bedford, MA, USA).
Lead researcher, assistant professor Xenia Gonda, said: "Biochemical studies have shown that the season in which you are born has an influence on certain monoamine
neurotransmitters, such as dopamine and serotonin, which is detectable even in adult life.
theory of MDD states that the symptoms of depression are because of reductions in the monoamine
neurotransmitters in the brain (Delgado, 2000).
"Since the 1950s, when antidepressants were discovered, we've focused on developing new agents that can better affect the monoamine
, norepinephrine, and dopamine [pathways]," he said.
The enzyme monoamine
oxidase B (MAO-B) serves a function in youth by keeping neurotransmitter levels from elevating too high.
Parallelly, neurochemical markers, that is, muscarinic receptors in lymphocytes (l-MRs) and monoamine
oxidase B in platelets (p-MAO-B), have been determined.