monoclonal antibody


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monoclonal antibody,

an antibody that is mass produced in the laboratory from a single clone and that recognizes only one antigen. Monoclonal antibodies are typically made by fusing a normally short-lived, antibody-producing B cell (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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) to a fast-growing cell, such as a cancer cell (sometimes referred to as an "immortal" cell). The resulting hybrid cell, or hybridoma, multiplies rapidly, creating a clone that produces large quantities of the antibody.

Monoclonal antibodies engendered much excitement in the medical world and in the financial world in the 1980s, especially as potential cures for cancer. They have been used in laboratory research and in medical tests since the mid-1970s, but their effectiveness in disease treatment was limited especially by the tendency of the early monoclonal antibodies to provoke an immune response against them because of the use of mouse cells in creating the hybridoma. This problem has been overcome through the use of recombinant DNA to produce chimeric and humanized monoclonal antibodies and of transgenic mice and other techniques to produce human antibodies. Monoclonal antibody therapies have been developed to treat transplant rejection, some autoimmune diseases, and some types of lymphoma, leukemia, and breast and other cancers. These therapies use monoclonal antibodies to home in on specific antigens found on the surface of targeted cells to deliver radioactive materials, drugs or inactive drug precursors (subsequent converted to a drug by an enzyme), tumor-suppressing genes, or substances that suppress or inhibit signaling molecules involved in disease processes.

Bibliography

See study by L. V. Marks (2015).

monoclonal antibody

[¦män·ə¦klō·nəl ′ant·i‚bäd·ē]
(immunology)
A highly specific antibody produced by hybridoma cells; the antibody binds with a single antigenic determinant.

monoclonal antibody

an antibody, produced by a single clone of cells grown in culture, that is both pure and specific and is capable of proliferating indefinitely to produce unlimited quantities of identical antibodies: used in diagnosis, therapy, and biotechnology
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