(49-52) Germline GATA2 mutation is associated with a broad spectrum of phenotypes, encompassing hematologic disease such as AML and MDS; infection characterized by viral, mycobacterial, and fungal infection; immunodeficiency with monocytopenia
; B- and NK-cell lymphocytopenia; skin conditions with warts and panniculitis; pulmonary disorder; and vascular/lymphatic dysfunction.
Results from this study demonstrate that capture, transport, and restraint for noninvasive diagnostic tests resulted in a relative leukopenia, lymphopenia, monocytopenia
, eosinopenia, increased H : L ratio, and unchanged venous blood pH, despite a mild respiratory acidosis and compensatory metabolic alkalosis.
It showed that the most important mortality prognostic factors for both Listeria bacteraemia and neurolisteriosis are multi-organ failure, aggravation of any pre-existing organ dysfunction, ongoing cancer, and monocytopenia
.  It is unfortunate that our patient had multiorgan failure, anaemia, septic shock and an altered mental state, despite being on adequate antibiotic treatment.
In this case, the heterophils were aberrantly high, which resulted to monocytopenia
or the lower count of monocytes.
Corticoid therapy causes lymphopenia, monocytopenia
and eosinopenia (28).
Hemato-biochemical analysis showed microcytic hypochromic anaemia, immune mediated thrombocytopenia, monocytopenia
, elevated ALP and ALT activities, hyperglobulinemia and hypoalbuminemia (Table 1).
DXM like the other corticosteroid drugs have long been known to cause immunosuppression through lymphocytopenia, monocytopenia
, and shrinkage of the spleen .
(4,17,18) For instance, infection due to Cunninghamella species, disseminated disease, active malignancy, and monocytopenia
were independent predictors of poor outcome, whereas salvage posaconazole-based therapy and neutrophil count recovery were predictive of a favorable outcome.
Mutations in the GATA2 gene lead to a primary immunodeficiency marked by progressive monocytopenia
, and B-cell and natural killer cell lymphopenia.
Regarding haematological parameters, monocytopenia
was seen in 5 (0.2%) patients, bicytopenia in 106 (61.2%) while 38 (21.9%) patients had pancytopenia at the time of presentation.
Factors independently associated with caspofungin resistance were recent echinocandin exposure, total parenteral nutrition (TPN), and monocytopenia
(absolute monocyte count <100 cells/mL, Table 3) or severe lymphopenia (absolute lymphocyte count <100 cells/mL [online Technical Appendix Table 2]).
XLN patients suffer from recurrent bacterial infections because of severe neutropenia and monocytopenia
[17, 18, 20] and they may develop cytogenetic changes indicative of chromosomal instability, myelodysplasia, or acute myeloid leukemia [18-20, 22].