monokine

Also found in: Dictionary, Medical, Wikipedia.

monokine

[′män·ə‚kīn]

(biochemistry)

A cytokine released from macrophages.

Mentioned in ?

tumor necrosis factor

References in periodicals archive ?

FGF-basic: basic fibroblast growth factor; GM-CSF: granulocyte-macrophage stimulating factor; IFN-[gamma]: interferon gamma; IL: interleukin; IP-10: inducible protein 10; KC: keratinocyte chemoat- tractant; MCP-1: monocyte chemotactic protein-1; MIG: monokine induced by IFN-[gamma]; MIP-[alpha] macrophage inflammatory protein-alfa; TNF-[alpha]: tumor necrosis factor alfa.

Interleukin-12 as a biomarker of the beneficial effects of food restriction in mice receiving high fat diet or high carbohydrate diet

A monokine regulates colony-stimulating activity production by vascular endothelial cells.

Assessment of serum levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) among non-segmental vitiligo patients: a pilot study

(12) IL-8 and the CXC chemokine, monokine induced by interferon gamma (Mig), seem to play an important role in the pathogenesis of VKC.

Vernal keratoconjuctivitis: a review

XCLl/lymphotactin-[alpha] XCL2/lymphotactin-[beta] CCL2-MCP-1: monocyte chemotactic protein-1; CCL3-MIP-la: macrophage inflammatory protein 1 alfa; CCL5-RANTES: regulated on activation, normal T expressed and secreted; CXCL8-IL-8: interleukin-8; CXCL9- MIG: monokine induced by gamma interferon; CXCL10-IP-10: interferon gamma-induced protein 10; CXCL11-I-TAC: interferon-inducible T-cell alpha chemoattractant.

Chemokines as potential markers in pediatric renal diseases

CXCL9/Mig, a monokine induced by interferon- (IFN-) gamma induced protein 1 (IP-10), is a type 1 C-X-C chemokine and displays strong chemoattraction for T-helper type 1 (Th 1) lymphocytes [57, 58].

Pathogenesis of chronic urticaria: an overview

The PPAR[gamma] ligands, 15d-PGJ2, troglitazone, and pioglitazone, can inhibit the IFN-[gamma]-induced expression of the CXC chemokines inducing protein-10 and monokine induced by IFN-[gamma]/IFN-inducible T-cell achemoattractant by endothelial cells [34].

PPAR[gamma] agonists in adaptive immunity: what do immune disorders and their models have to tell us?

In contrast the monokine MIG, also involved in immune activity, was elevated.

Researchers find 9 proteins that can map aging process

[]Biomaterials-induced macrophage activation and monokine release[], J.

Gelatin [] glutaralgehyde modified vitelline membrane of hen's egg supports growth of adherent cells in vitro

The concentration of this monokine in umbilical blood serum of newborns of mothers with intrauterine infections had no significant differences from control values in the peripheral blood of healthy newborns; it made 179.8 [+ or -] 8.20 pg/ml.

Features of balance of proinflammatory and anti-inflammatory cytokines in newborns with herpes virus infections

(16) These data are well in line with the observation that in human PBMC, DMF inhibits lipopolysaccharide (LPS)-induced secretion of IL-8, monokine induced by IFN-[gamma] (Mig) and IP-10, all NF-[kappa]B dependent chemokines.

Spotlight on fumarates

T cells, representing the adaptive arm of the immune response, also play a critical role in atherogenesis, entering lesions in response to the chemokineinducible protein-10, monokine induced by interferon (IFN)-[gamma], and IFN-inducible T cell [alpha]-chemo-attractant (31).

Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction

Table 2-3 Some Types of Cytokines and Their Functions Type Source Function Interleukin-1 Monokine produced by Activates B and activated macrophages T lymphocytes; mediates inflammation Interleukin-2 Lymphokine produced by Growth factor for B and helper T cells T lymphocytes; enhances cytotoxic effects of nonkiller (NK) cells Interferon Lymphokine produced by Activates macrophages; helper and suppressor promotes B- and T-cell T cells differentiation; activates neutrophils and NK cells Tumor necrosis Monokine produced by Mediator of inflammation factor activated macrophages Table 2-4 Phases of Acquired Immunity Phase Action Recognition Exposure to a specific antigen resulting in selective activation and expansion of those lymphocytes with antigenic receptors specific for that antigen.