mononuclear

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Related to mononuclear phagocytes: thymus, reticuloendothelial cells

mononuclear

[¦män·ō′nü·klē·ər]
(cell and molecular biology)
Having only one nucleus.
References in periodicals archive ?
Together with dendritic cells (DCs) and monocytes, macrophages are major components of the mononuclear phagocyte system.
Low numbers of mononuclear phagocytes were also present and were occasionally noted to have a cytoplasmic vacuole containing small, thin, variably staining, linear to pleomorphic structures, consistent with bacteria (Fig 3).
Frymuller et al., "Mouse B-1 cell-derived mononuclear phagocyte, a novel cellular component of acute non-specific inflammatory exudate," International Immunology, vol.
The best characterized of these is the receptor for advanced glycation end products (RAGE), which is expressed by multiple cell types including endothelium and mononuclear phagocytes. RAGE plays a central role in oral infection, exaggerated inflammatory host responses, and destruction of alveolar bone in diabetes.
Briefly, mononuclear phagocytes and bacteria were mixed and incubated for 30 min to allow phagocytosis.
"System of mononuclear phagocytes and biologic effects proinflammatory cytokines," Russian Journal of gastroenterology, hepatology, coloproctology [Rossiyskiy zhurnal gastroenterologii, gepatologii koloproktologii], in Russian, Vol.8(5), pp.7-13
T-helper cells produce chemokines and cytokines which bring about amplification of cellular immune response and migration of mononuclear phagocytes and other inflammatory cells into the tissues.
Human monocytotropic ehrlichiosis (HME) is an emerging tick-borne disease caused by the obligately intracellular pathogen Ehrlichia chaffeensis that resides in mononuclear phagocytes. HME initially manifests as nonspecific flu-like symptoms but can progress to life-threatening toxic shock-like syndrome with anemia, thrombocytopenia and multi-organ failure.
Desport (microbiology and immunobiology, School of Veterinary and Biomedical Sciences, Murdoch U., Australia) presents 12 chapters exploring current knowledge of the biology and pathogenesis of lentiviral induced disease that occurs following infection of mononuclear phagocytes (i.e., blood-borne macrophages, tissue histiocytes, dendritic cells, and microglia) that serve as reservoirs and vehicles for pathogen dissemination and in disease induction.
In either case, drug combinations can provide a greater effect than either drug alone.Treating tumors with nanoparticles has been challenging because immune cells called mononuclear phagocytes identify them and yank them from circulation, preventing the nanomaterials from reaching their target.Ji-Ho Park, a graduate student in Sailor's UC San Diego laboratory, and Geoffrey von Maltzahn, a graduate student in Bhatia's MIT laboratory, headed the effort to develop two distinct nanomaterials that would work in concert to overcome that obstacle and others.