morphine

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morphine,

principal derivative of opiumopium,
substance derived by collecting and drying the milky juice in the unripe seed pods of the opium poppy, Papaver somniferum. Opium varies in color from yellow to dark brown and has a characteristic odor and a bitter taste.
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, which is the juice in the unripe seed pods of the opium poppypoppy,
common name for some members of the Papaveraceae, a family composed chiefly of herbs of the Northern Hemisphere having a characteristic milky or colored sap. Most species are native to the Old World; many are cultivated in gardens for their brilliantly colored if
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, Papaver somniferum. It was first isolated from opium in 1803 by the German pharmacist F. W. A. Sertürner, who named it after MorpheusMorpheus
, in Greek and Roman mythology, god of dreams. The son of Hypnos (or Somnus), the god of sleep, he brought dreams of human forms. His brothers Phobetor and Phantasos induced dreams of animals and inanimate objects, respectively.
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, the god of dreams. Given intravenously, it is still considered the most effective drug for the relief of pain.

See also drug addiction and drug abusedrug addiction and drug abuse,
chronic or habitual use of any chemical substance to alter states of body or mind for other than medically warranted purposes. Traditional definitions of addiction, with their criteria of physical dependence and withdrawal (and often an underlying
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.

Effects and Uses

Morphine, a narcoticnarcotic,
any of a number of substances that have a depressant effect on the nervous system. The chief narcotic drugs are opium, its constituents morphine and codeine, and the morphine derivative heroin.

See also drug addiction and drug abuse.
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, acts directly on the central nervous system. Besides relieving pain, it impairs mental and physical performance, relieves fear and anxiety, and produces euphoria. It also decreases hunger, inhibits the cough reflex, produces constipation, and usually reduces the sex drive; in women it may interfere with the menstrual cycle.

Morphine is highly addictive. Tolerance (the need for higher and higher doses to maintain the same effect) and physical and psychological dependence develop quickly. Withdrawal from morphine causes nausea, tearing, yawning, chills, and sweating lasting up to three days. Morphine crosses the placental barrier, and babies born to morphine-using mothers go through withdrawal.

Today morphine is used medicinally for severe pain, cough suppression, and sometimes before surgery. It is seldom used illicitly except by doctors and other medical personnel who have access to the drug. It is injected, taken orally or inhaled, or taken through rectal suppositories. Methadonemethadone
, synthetic narcotic similar in effect to morphine. Synthesized in Germany, it came into clinical use after World War II. It is sometimes used as an analgesic and to suppress the cough reflex.
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 treatment has been useful in curing morphine addiction.

History

Morphine was first used medicinally as a painkiller and, erroneously, as a cure for opium addiction. It quickly replaced opium as a cure-all recommended by doctors and as a recreational drug and was readily available from drugstores or through the mail. Substitution of morphine addiction for alcohol addiction was considered beneficial by some physicians because alcohol is more destructive to the body and is more likely to trigger antisocial behavior. Morphine was used during the American Civil WarCivil War,
in U.S. history, conflict (1861–65) between the Northern states (the Union) and the Southern states that seceded from the Union and formed the Confederacy.
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 as a surgical anesthetic and was sent home with many wounded soldiers for relief of pain. At the end of the war, over 400,000 people had the "army disease," morphine addiction. The Franco-Prussian War in Europe had a similar effect.

In 1906 the Pure Food and Drug Act required accurate labeling of patent medicines and tonics. Various laws restricting the importation of opium were enacted, and the Harrison Narcotics Act (1914) prohibited possession of narcotics unless properly prescribed by a physician. Despite legislation, morphine maintained much of its popularity until heroinheroin
, opiate drug synthesized from morphine (see narcotic). Originally produced in 1874, it was thought to be not only nonaddictive but useful as a cure for respiratory illness and morphine addiction, and capable of relieving morphine withdrawal symptoms.
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 came into use, it in its turn believed to be a cure for morphine addiction.

Bibliography

See publications of the Drugs & Crime Data Center and Clearinghouse, the Bureau of Justice Statistics Clearinghouse, and the National Clearinghouse for Alcohol and Drug Information.

Morphine

 

an alkaloid of opium, a medicinal preparation of the group of analgesics.

Morphine hydrochloride is prescribed by physicians to relieve pain resulting from injuries and severe pain accompanying various diseases. It is also used in preparing a patient for surgery and in the postoperative period. Morphine is sometimes used to alleviate severe dyspnea owing to cardiac insufficiency. The prolonged use of morphine may result in addiction to the drug.

morphine

[′mȯr‚fēn]
(pharmacology)
C17H19NO3·H2O A white crystalline narcotic powder, melting point 254°C, an alkaloid obtained from opium; used in medicine in the form of a hydrochloride or sulfate salt.

morphine

, morphia
an alkaloid extracted from opium: used in medicine as an analgesic and sedative, although repeated use causes addiction. Formula: C17H19NO3
References in periodicals archive ?
Prolonged use of morphine sulfate tablets during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated.
in the present study morphine sulfate was used as a post arthrocentesis intra-articular injection.
Morphine sulfate ([10.sup.-4] M) alone had no effect on the observed frequency of micronucleated binucleate cells, whereas mitomycin C (1.5 x [10.sup.-7] M) increased the frequency approximately 9-fold (Table 1).
In reading many of the earlier papers on inhaled opioids I was struck by a high degree of what I would refer to as "nebulizer naivete." Statements to the effect that "the patient was given 10 mg of morphine sulfate by nebulizer every 4 hours" were quite common.
From 1st September 2019, KAPANOL (morphine sulfate pentahydrate) is expected to be listed on the PBS as a restricted benefit for chronic breathlessness in addition to its current listing for use in chronic severe disabling pain.
According to the company, the Prometra Programmable Infusion Pump System is indicated for intrathecal infusion of drug therapy, Infumorph (preservative free morphine sulfate sterile solution), preservative-free sterile 0.9% saline solution (Sodium Chloride Injection, USP) as well as baclofen (baclofen injection, intrathecal, 500-2000 mcg/ml).
Some of Zydus' recent launches include potassium chloride extended-release tablets 8mEq, etomidate injection, morphine sulfate extended-release tablets, isosorbide mononitrate extended-release tablets, and pyridostigmine bromide tablets.
A concentrated oral solution of morphine sulfate has been approved by the Food and Drug Administration, rescuing a formulation that had been slated to be taken off the market last year until physician groups spoke up about its clinical utility and lack of equivalent products.
The Food and Drug Administration has backed off from a warning letter it sent to several manufacturers and decided to allow an unapproved version of high-concentrate morphine sulfate oral solution to remain on the market.
Men with nonmalignant pain (average age 47 years), using either methadone 30 mg/day, morphine sulfate 30 mg/day, or transdermal fentanyl 25 [micro]g/hour for at least 6 months, were eligible for the study if their free testosterone levels were below 50 pg/mL.
Morphine Sulfate Injection BP 30 mg in 1 mL ampoule is not safe to be used for either the epidural or intrathecal routes.
earlier this month announced that the Food and Drug Administration has approved morphine sulfate injection, USP to be offered in the BD Simplist line of ready-to-administer prefilled injectables in the most common strengths: 2 mg/mL, 4 mg/mL, 5 mg/mL, 8 mg/mL and 10 mg/mL.