The retention type had an intact epithelial lining which was filled with mucin
and inflammatory debris Fig 3,4.
They are further subclassified by the amount of tumor cells with evident intracytoplasmic mucin
into NOS (>50% of tumor cells with intracytoplasmic mucin
; Figure 2, A), intestinal type (>50% of cells with goblet morphology; Figure 2, B and C), or signet ring cell type (>50% of tumor cells with signet ring morphology; Figure 2, D).
Glycosylated proteins called mucins
line the gut wall, providing sugars that serve as attachment points for gut bacteria while also feeding them as they assist in digestion.
Findings included low-grade atypia in the epithelium (11 cases), loss of the muscularis mucosa layer (9 cases), submucosal fibrosis (11 cases), presence of acellular mucin
inside the appendiceal wall (11 cases), appendiceal rupture (0 case), undulating or stratified epithelial growth (5 cases), lymphoid tissue atrophy (8 cases), and pushing invasion (1 case).
Caption: Figure 2 - Histopathology image of the tumor a) - Photomicrograph showing uninvolved epidermis (Vertical arrow), the dermis showing nests and clusters of tumor cells lying in the pool abundant mucin
(Horizontal arrow) (Hematoxylin & Eosin 100X).
Histopathological examination revealed widespread mucin
accumulation with alcian and colloidal iron stains in the papillary and reticular dermis (Figure 3).
To obtain insight into the mechanism of mucoadhesive NP with VRZ: mucin
interaction, ZP measurements of their dispersions were performed and the results are shown in Figure 3A.
Recent studies have shown that excessive oxidative stress plays an important role in MUC5AC mucin
Overexpression of 5AC mucin
was found not only in pancreatic neoplasia but also in precursor lesions: in intraductal papillary mucinous neoplasms (IPMN) and pancreatic mucinous cystic neoplasms (MCN).
The presence of mucin
in the neuroendocrine component is reminiscent of goblet cell carcinoid.
The infiltrating components of these extra-prostatic mucinous cancers contain mucin
pools lined by columnar mucinous epithelium and show different degrees of nuclear atypia.