: difficulties in diagnosis and treatment [in French].
We would like to present two immunocompetent cases with mucormycosis
which had major trauma and were given corticosteroids in our clinic in 2016-2017.
A Invasive candidiasis (n=32) 33% Aspergillosis ( n=22) 23% Histoplasmosis (n=19) 19% Cryptococcosis (n=7) 7% Mucormycosis
(n=6) 6% Cladosporiosis (n=s) 5% Coccidiomycosis (n=3) 3% Unspecified (n=2) 2% Fusariosis (n=1) 1% Pneumocystosis (n= 1) 1% Note: Table made from pie chart.
, Aspergillosis, Amphotericin B.
Amphotericin B is the preferred drug for disseminated/severe fungal diseases including cryptococcosis, coccidioidomycosis, paracoccidioidomycosis, histoplasmosis, blastomycosis, mucormycosis
(zygomycosis) for induction therapy, and sporotrichosis [4, 5].
Because high-grade fever was not resolved in 8th day of therapy (24 April), the blood sample was sent for a new culture, polymerase chain reaction (PCR; for aspergillosis, mucormycosis
, candida, CMV, and tuberculosis), and enzyme-linked immunosorbent assay (ELIZA; for toxoplasmosis and cytomegalovirus antibody assay).
Zygomycosis, also referred to as phycomycosis or mucormycosis
, is an aggressive and rapidly progressive infection that primarily occurs in immunocompromised patients.
Among the oral manifestations related to DM described are dry mouth, tooth decay, periodontal disease and gingivitis, oral candidiasis, burning mouth syndrome (BMS), taste disorders, rhinocerebral zygomycosis (mucormycosis
), aspergillosis, oral lichen planus, geographic tongue and fissured tongue, delayed wound healing and increased incidence of infection, salivary dysfunction, altered taste and other neurosensory disorders, impaired tooth eruption, and benign parotid hypertrophy.
The most recent azole to be approved for use against invasive aspergillosis and invasive mucormycosis
infections is isavuconazole.
Maier, "Rhino-orbital-cerebral mucormycosis
and aspergillosis: Differential diagnosis and treatment," European Archives of Oto-Rhino-Laryngology, vol.
is a rare but life-threatening, rapidly progressive infection that occurs in immunocompromised patients with mortality as high as 76% that is 10-50 times less likely than aspergillus or candida infection [1-3].
Surgical approaches should be reserved for patients with pleural hemorrhage, uncontrolled hemoptysis, or aggressive infections that may not respond to medical therapy alone (e.g., mucormycosis