multiple hereditary exostoses


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multiple hereditary exostoses

[′məl·tə·pəl hə′red·ə‚ter·ē ‚ek·səs′tō·sēz]
(medicine)
An inherited form of exostosis, revealing itself at several sites in childhood or adolescence. Also known as diaphyseal aclasis; hereditary deforming chondrodysplasia; metaphyseal aclasis; multiple cancellous exostoses; multiple cartilaginous exostoses.
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In multiple hereditary exostoses, bone growths are usually observed in relation to the metaphysis of the bone and characterized by the growth of cartilage capped benign bone tumors around areas of active bone growth, particularly the metaphysis of the long bone.
About 85% are solitary, rest are seen as a part of Multiple hereditary exostoses.
CLINICAL SIGNIFICANCE: Multiple hereditary exostoses may produce bone deformities, shortened stature, limb length discrepancies, decreased range of motion, fatigue, pain, muscle irritability and premature osteoarthritis.
Femur with multiple exostoses

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