muscarine

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muscarine

[′məs·kə‚rēn]
(organic chemistry)
C8H19NO3 A quaternary ammonium compound, the toxic ingredient of certain mushrooms, as Amanita muscaria. Also known as hydroxycholine.
References in periodicals archive ?
The Company's pipeline is built on the broad therapeutic potential of KarXT and the established link between muscarinic receptor stimulation in the CNS and its ability to impact a wide range of disorders including schizophrenia, Alzheimer's disease and various forms of pain.
"There have been studies comparing long-acting muscarinic antagonists to long-acting beta-agonists, and the long-acting muscarinic antagonists like tiotropium seem to be superior," she said.
"There's been studies comparing long-acting muscarinic antagonists to long-acting beta-agonists, and the long-acting muscarinic antagonists like tiotropium seem to be superior," she said.
The company offers KarXT that targets the muscarinic acetylcholine receptors for the treatment of schizophrenia and is composed of xanomeline, a novel clinical-stage muscarinic acetylcholine receptor agonist (activator); and trospium chloride, an FDA-approved muscarinic receptor antagonist (blocker) that has been shown not to enter the central nervous system.
Five muscarinic receptor subtypes, [M.sub.1], [M.sub.2], [M.sub.3], [M.sub.4] and [M.sub.5] have been identified.
Long-Acting Muscarinic Antagonist in Combination with Long-Acting Beta[sub]2-Adrenoceptor Agonist
Muscarinic features (99.65%) were the predominant clinical feature followed by CNS (87.26%) and nicotinic manifestations (78.53%).
Acetylcholine has been reported to mediate its actions via muscarinic receptors (M1, M2, M3, M4, and M5).
conceptionis indicated the presence of two muscarinic receptors of high and low sensitivity to acetylcholine supporting a contraction mechanism related to muscarinic receptors (Moraga and Urriola-Urriola, 2014, 2015).
Trimbow is the first 3-in-1 combination inhaler containing an inhaled corticosteroid (ICS) / long-acting [beta]2-agonist (LABA) / long-acting muscarinic antagonist (LAMA) containing beclometasone dipropionate (BDP; 87mcg), formoterol fumarate (FF, 5mcg) and glycopyrronium (GB, 9mcg), administered as a twice-daily fixed-dose in a pressurised metered-dose inhaler (pMDI) extrafine formulation.
The closed triple combination therapy comprises three medicines: fluticasone furoate, an inhaled corticosteroid (ICS), umeclidinium, a long-acting muscarinic antagonist (LAMA) and vilanterol, a long-acting beta2-adrenergic agonist (LABA), delivered once-daily in GSK's Ellipta dry powder inhaler.
Acetylcholine (ACh) is the natural ligand of the muscarinic cholinergic membrane receptor (mAChR), which belongs to the superfamily of G protein-coupled receptors.