musk ketone

musk ketone

[′məsk ′kē‚tōn]
(organic chemistry)
C14H18N2O5 White to yellow crystals with sweet musk aroma; soluble in various oils and phthalates, insoluble in water; used as a perfume fixative. Also known as 3,5-dinitro-2,6-dimethyl-4-tert-butylacetophenone.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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"Among them are chemicals associated with hormone disruption and allergic reactions, and many substances that have not been assessed for safety in personal care products." EWG adds that some of the undisclosed ingredients are chemicals "with troubling hazardous properties or with a propensity to accumulate in human tissues." Examples include diethyl phthalate, a chemical found in 97 percent of Americans and linked to sperm damage in human epidemiological studies, and musk ketone, which concentrates in human fat tissue and breast milk.
THE SYNTHETIC fragrance musk ketone has been correctly declared a carcinogen with the same potential dangers to consumers as musk xylene, a European Commission committee has concluded.
From 1995 to 2000, the total worldwide usage declined from 300 tons to 200 tons for musk xylene and musk ketone combined.
IC10) Lowest NOEC (mg/L) (mg/L MK 0.14 mmol = 0.041 0.063 MX 0.09 mmol = 0.027 0.056 AHTN 0.35 mmol = 0.090 0.035 HHCB 0.37 mmol = 0.095 0.068 Abbreviations: MK, musk ketone; MX, musk xylene.
Efflux transport remained compromised 48 hours after exposure in tissue treated with certain commonly used compounds: musk xylene, musk ketone, Galaxolide, and Celestolide.
Musk ketone (MK), MX, HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8, 8-hexamethyl-cyclopenta-[gamma]-[2]-benzopyran), and Celestolide (ADBI; 4-acetyl-1, 1-dimethyl-6-tert-butylindane) were gifts from International Flavors & Fragrances Inc.
Musk ketone enhances benzo(a)pyrene induced mutagenicity in human derived Hep G2 cells.
Evaluation of health risks caused by musk ketone. Int J Hyg Environ Health 203(4):293-299.
Environmental risk assessment of musk ketone and musk xylene in the Netherlands in accordance with the EU-TGD.