mutation fixation

[myü′tā·shən fik‚sā·shən]

(cell and molecular biology)

The condition of changing a premutational deoxyribonucleic acid lesion to mutation.

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This outcome is likely because all tissues are mitotically active during in utero development and therefore are susceptible to mutation fixation; in contrast, adult liver and brain have very low mitotic indices.

In Utero exposure to benzo[a]pyrene increases mutation burden in the soma and sperm of adult mice

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