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Related to myasthenic: Myasthenic crisis


Muscular weakness.



(asthenic bulbar paralysis, asthenic ophthalmoplegia, pseudobulbar paralysis, Erb-Goldflam disease), a neuromuscular disease characterized by the pathological, rapid fatigability of striated muscles.

The onset of myasthenia usually occurs between the ages of 20 and 40 years; women are more frequently affected, Autoimmune processes play a part in the development of the disease; antibodies have been discovered in muscle tissue and in the thymus gland. The muscles of the eyelids are often affected and there is ptosis, which varies in degree during the day; the masticatory muscles are affected, swallowing is disrupted, and the gait changes. Treatment includes anticholinesterase preparations, vitamins (especially B-group), general restorative treatment, and sometimes the removal of the thymus gland.


Lobzin, V. S. Miasteniia. Leningrad, 1960.
Shefer, D. G. Gipotalamicheskie (dientsefal’nye) sindromy, 2nd ed. Moscow, 1971.
References in periodicals archive ?
The patient we report had a myasthenic crisis associated with a new ST of L.
'It is a matter of great satisfaction to learn that Australian Aid has been providing significant financial assistance to the Pakistan Myasthenic Welfare Organisation (PMWO) for provision of advance health care facility of plasmapheresis in Pakistan through Plasmapheresis Excellence Centres in teaching hospitals,' he said, adding 'many precious lives have been saved through this treatment.'
Myasthenic syndrome in patients with amyotrophic lateral sclerosis.
Myasthenic crisis involves a sudden onset of severe muscle weakness that can cause respiratory failure, meaning the patient requires intubation and ventilation, It can be caused by a lack of anticholinesterase medication or precipitating factors such as infection, surgery or stress.
Tracheoesophageal Fistula Caused by Tracheostomy in a Patient with Myasthenia Gravis after a Myasthenic Crisis.
The hallmark of myasthenic crisis is the bulbar and/ or respiratory weakness.
Data of patients Case Age Sex Paraneoplastic neurological syndromes 1 90 F Subacute cerebellar degeneration 2 56 F Subacute cerebellar degeneration 3 63 M Stiff-person syndrome 4 57 F Stiff-person syndrome 5 44 F Stiff-person syndrome 6 60 M Lambert-Eaton myasthenic syndrome 7 53 M Sensory neuronopathy 8 56 M Limbic encephalitis 9 54 M Limbic encephalitis Case Main associated tumors Paraneoplastic antibodies 1 Breast Anti-Yo 2 Small-cell lung cancer Anti-Hu 3 Not detected Anti-GAD 4 Thyroid Anti-GAD 5 Breast Not evaluated 6 Small-cell lung cancer Not evaluated 7 Lung adenocarcinoma Anti-Yo 8 Testicle Negative 9 No tumor LGI1 F: Female, M: Male, LGI1: Leucine-rich glioma inactivated 1, GAD: Glutamic acid decarboxylase Table 2.
In one study, approximately 43% of myasthenic patients did not have clinically detectable limb weakness at the time of diagnosis [37].
Thyrotoxicosis is seen in 5 percent of myasthenic patients, and other autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, mixed connective tissue disease, polymyositis and aplastic anemia can be associated with MG.
Lambert-Eaton myasthenic syndrome (LEMS) is a rare neuromuscular junction disorder resulting from the development of auto-antibodies against voltage-gated calcium channels (VGCCs) in pre-synaptic terminals (1).
The clinical presentations of the 1st patient were similar to myasthenic crisis and she, therefore, received plasma exchange.