We discovered that they not only digest myelin
following injury, but they also induce the disintegration of the long axon segments that are separated from their cell bodies due to the injury," points out Claire Jacob.
Using this knowledge, the UMSOM researchers determined that under the right conditions, these melanocyte stem cells could function as cells that produce myelin
, the major component of a structure known as the myelin
sheath, which protects neurons and is vital to the function of our nervous system.
The researchers reported that certain astrocytes inhibit an enzyme called thrombin to alter myelin
and the speed of nerve signals.
The erosion of the myelin
sheath interrupts the transmission of signals along nerves, which causes the symptoms of MS, such as vision problems, muscle weakness, and difficulty with coordination and balance.
The company's thesis is that therapeutics that act directly within the central nervous system to stimulate myelin
regeneration may be what is needed to stop or reverse the progressive nature of these types of diseases altogether.
Convelo is pioneering approaches to regenerate the protective myelin
coating around nerve cells that is lost in a wide array of neurological diseases including multiple sclerosis, pediatric leukodystrophies, traumatic injury and age-related pathologies such as Alzheimer's.
is composed of compacted lipid membranes that wrap around the axons of many neurons, providing electrical insulation and trophic support.
They found that when fibrinogen (a blood-clotting protein) leaks into the central nervous system, it stops brain cells from producing myelin
and, as a result, prevents repair.
In the present study, we examined the localization of DCUN1D2 and NEDD8 in the sciatic nerves, and found that these neddylation-related molecules were present mainly in the myelin
paranodal regions and Schwann cell bodies.
Rich Levy, CEO of Myelin
, a Baird Capital portfolio company, will become chairman of both companies.
How oligodendrocytes work together to wrap nerve fibers in myelin
becomes evident in Brainbow photos of the roughly 3-millimeterlong optic nerve, the team reports in the April Glia.
sheath thickening in D-gal-treated fibers may result from intra-myelin degeneration such as loosening or splitting of the myelin
lamellae which ultimately alters the ratio of the sheath thickness to the fiber diameter.