Nutritional deficiency affecting myelination
of peripheral nerves might be the cause for significantly decreased sensory nerve conduction velocity in severely malnourished children, but whether these changes in nerve conduction can be reversed or not by nutritional rehabilitation needs to be evaluated by further studies.
We can infer from the results that the white matter of the 200 mg/kg group or the 600 mg/kg group is intact, with the presence of the intact pyramidal cells, and neuronal damage of any significance would affect the myelination
of the white matter.
The SCs have been shown to be targets for GDNF, with this NTF maintaining their migration and stimulating myelination
[7, 8, 32].
Gray matter myelination
is much less understood and may be regulated differently due to the distinct microenvironments of the white and gray matter.
To determine its correlation with potential clinical symptoms of ASD, we therefore planned to investigate neural transmission within the visual system using VEP as an index of the myelination
process of the visual pathway and its correlation to the clinical severity of autism.
Especially the high ratio of myelination
of axons in this BMPS (up to 40%) is significant, as only a few models have displayed this process in vitro previously.
PMD is usually suspected by the presence of typical neurological findings in physical examination and abnormal myelination
in Magnetic Resonance Imaging (MRI).
A prenatal ultrasound at 20 weeks revealed enlarged ventricles and enlarged posterior fossa fluid spaces, while a postnatal brain MRI demonstrated a delayed myelination
pattern, enlarged gyri, cerebellar hypoplasia, and enlarged ventricles including lateral, third, and fourth; findings were consistent with Dandy-Walker Malformation.
Recently, a large number of studies have been focusing on epigenetics research of SCs related to PNS injury, and some studies [11-14] have showed that microRNAs and histone deacetylases of SCs emphasized the importance of epigenetic mechanisms for peripheral myelination
after PNS injury.
[1,2] Iron plays a key role in the central nervous system (CNS) functions such as myelination
; synaptogenesis; and synthesis of neurotransmitters such as dopamine, catecholamine, serotonin, and possibly GABA.
Since this metabolic pathway plays a significant role in myelination
of nerve fibers, the growth and development of the child would also be adversely affected.
Microglial phospholipase D4 deficiency influences myelination
during brain development Terumasa CHIBA, Yoshinori OTANI, Yoshihide YAMAGUCHI, Tomoko ISHIBASHI, Akiko HAYASHI, Kenji F.