Granulocyte colony stimulating factor increases the number of neutrophils and decreases the frequency of infections by correcting the pause in maturation of
myelocytes. The patients are not lost because of infection.
Results: Our data show increased infiltration of lymphocytes (mean lymphocytes = 287.6cells/mm2) as well as
myelocytes (mean lymphocytes = 117.1cells/mm2) in pre-neoplastic tissues.
1: Bone marrow aspiration showing myeloid series,
myelocytes and metamyelocytes with features of dysmyelopoiesis.
His hemoglobin level was 11.6 g/dl, platelet count 1.86 x 109 /L and total leukocyte count (TLC) 58x [10.sup.9]/L, which included 8% blasts, 51%
myelocytes and metamyelocytes, 24% neutrophils, 16% lymphocytes, and 1% basophils.
For abnormal WBCs, the 3 most common findings were atypical lymphocytes (18 occurrences), blasts (9 occurrences), and
myelocytes (6 occurrences).
The incidence of sheathing of veins in myeloid leukemia can be explained by the greater tendency of leukemic infiltration of
myelocytes than lymphocytes (Burgeson and Wegner 1929).
% RBC morphology 22 51.2 23 53.5 17 58.6 Platelet morphology 11 25.6 12 27.9 9 31.0 Metamyelocyte,
myelocyte, 9 20.9 7 16.3 2 6.9 promyelocyte Atypical lymphocyte 2 4.7 1 2.3 1 3.4 WBC morphology 1 2.3 2 4.7 0 0.0 NRBC 0 0.0 1 2.3 0 0.0 Blast 0 0.0 0 0.0 0 0.0 Total 43 100.0 43 100.0 29 100.0 Abbreviations: NRBC, nucleated red blood cell; RBC, red blood cell; WBC, white blood cell.
Counts: Neutrophils: 61, Lymphocyte: 07, Monocyte: 06, Eosinophil: 05, Basophils: 04, Band forms: 03 Metamyelocyte: 04,
Myelocyte: 04, Blast: 06, Platelets count: 4 Lakhs/Cu mm.
All stages of eosinophilic maturation can be identified, which exhibit immature eosinophilic cytoplasmic granules, mainly evident at the promyelocyte and
myelocyte stages (Figure C).
It was not found the presence of basophils, atypical lymphocytes,
myelocytes, metamyelocytes, blasts in farm workers.
Haematopoiesis relates to the development of three important lineages: Lymphocytes,
myelocytes and erythroid cells.
* Immature granulocytes (includes promyelocytes,
myelocytes, metamyelocytes)
