myelofibrosis


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.

myelofibrosis

[‚mī·ə·lō·fī′brō·səs]
(pathology)
Growth of white, fibrous connective tissue in the bone marrow.
References in periodicals archive ?
Myelofibrosis is an uncommon and a particular type of life-threatening blood cancer (myeloid neoplasm) characterized by bone marrow failure, enlarged spleen (splenomegaly) and debilitating symptoms, severely impacting people's quality of life.
(1) Therefore, bone marrow biopsy is essential for the diagnosis of bone marrow failure, myelodysplastic anemia, myelofibrosis, metastatic disease, and other disorders/tumors.
Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1low mouse model of the disease.
Since the patient had pancytopenia and TAFRO syndrome was a possible explanation for this laboratory finding, a bone marrow biopsy was performed, which revealed myelofibrosis which was a key criterion of this syndrome.
We believe Celgene is the ideal organization to follow through on our mission of maximizing fedratinib's potential for patients with myelofibrosis."
When the described patient arrived with diagnosis of myelofibrosis, the initial thought was to treat this like a fibrosis problem because of the known lack of success from other therapeutic concepts.
Polycythemia vera (PV), idiopathic myelofibrosis (IMF), and essential thrombocytosis (ET) have been traditionally classified under the "the non CML chronic myeloproliferative neoplasms"2 because they share the features: involvement of a multipotent hematopoietic progenitor cell.6 Dominance of the transformed clone over non-transformed hematopoietic progenitor cells.7-9
These findings were compatible with idiopathic myelofibrosis. We were unable to do a cytogenetic analysis as the facility was not available to us.
Efficacy of ruxolitinib in Korean myelofibrosis patients and cases complicated TB lymphadenitis during the treatment.
There have also been individual cases of primary myelofibrosis associated with DM [4,12,13].
Without the first course of treatment in 2004 Eric would have been too weak to have surgery for a separate face cancer he suffered while battling myelofibrosis.
[USPRwire, Fri Nov 06 2015] GlobalData's clinical trial report, "Thrombocythaemia Myelofibrosis Global Clinical Trials Review, H2, 2015" provides an overview of Thrombocythaemia Myelofibrosis clinical trials scenario.