myeloid metaplasia


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myeloid metaplasia

[′mī·ə‚lȯid ‚med·ə′plā·zhə]
(medicine)
The occurrence of hemopoietic tissue in abnormal places in the body.
References in periodicals archive ?
CONCLUSION: Pilomatricoma is an uncommon tumor but still rarer is the one with extensive areas of calcification, ossification and formation of myeloid metaplasia.
A review of the Myeloid Metaplasia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
A phase 2 trial of combination low dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia.
Chronic idiopathic myelofibrosis (CIMF) is characterized by splenomegaly, myeloid metaplasia and reactive bone marrow fibrosis, and it has the highest karyotype aberration rate (1-3).
It can be distinguished from agnogenic myeloid metaplasia by the absence of splenomegaly, teardrop RBCs and leukoerythroblastosis in peripheral blood smears, and from acute megakaryoblastic leukemia by the absence or small percentages of blasts of megakaryocytic origin [17].
Gemin X recently initiated Phase 2 clinical trials with GX15-070 in patients with Hodgkin's Lymphoma and in myelofibrosis with myeloid metaplasia.
Additionally, Incyte believes there is strong genetic and early clinical evidence suggesting that blocking signaling through the JAK2 pathway may provide therapeutic benefits in a number of myeloproliferative diseases (MPDs), such as polycythemia vera, essential thrombocythemia and myeloid metaplasia.
GX15-070 is currently being evaluated in Phase 2 trials as a 24-hour infusion every two weeks in the treatment of Hodgkin's lymphoma and myelofibrosis with myeloid metaplasia.
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