Generalized marrow expansion is a response to a systemic process, such as anemias, tumors, and other myelophthisic
Bone marrow examination can also detect myelophthisic
disorders, such as acute leukemia, lymphoma, or metastatic malignancy, which could explain a patient's thrombocytopenia.
Immunological and Hematological Disorders: Patients with AIDS, hemoglobinopathies, immunologically mediated hemolytic processes, myelophthisic
conditions, sickle cell anemia, systemic lupus erythematosus, beta thalassemia, or chronic hemolytic anemia (from conditions such as multiple cardiac valve replacement) often respond poorly to conventional Epoetin alfa dosing regimens.
Giant basal cell carcinoma with metastases and myelophthisic
anemia secondary to rectal carcinoma is unprecedented in our experience and consistent with previous observations that bony metastases are rare.[1,2] The finding of a myelophthisic
process in a patient undergoing radical resection for localized rectal carcinoma may, therefore, direct consideration toward a primary hematologic malignant neoplasm or a second malignant neoplasm metastatic to the bone marrow.