Focal areas with eosinophils were present, with increased myelopoiesis
(Figure 1, a).
GM-CSF is a growth factor that stimulates the development of myeloid cells, or myelopoiesis
, via its receptors, and is synthesized mainly by stromal cells in the bone marrow (8).
The zinc finger gene MZF-1 is preferentially expressed in primitive hematopoietic cells and plays an important role in regulating myelopoiesis
(Hromas et al.
Resident hematopoietic cells in the bone marrow serve as important contributors of erythropoiesis, myelopoiesis
, lymphopoiesis, and bone turnover.
Megakaryocytes are also formed during myelopoiesis
and these ultimately liberate cytoplasmic contents into the circulation as platelets.
HIV-induced abnormalities in myelopoiesis
are also associated with recovery following ART, shown by normalisation of colony-forming units of the erythrocyte, granulocyte and monocyte cell lines after using ART for 6 months in HIV-infected patients.
Eventually the child recovers from the respiratory infection, but with suppressed myelopoiesis
the child may become infected again, and this cycle of infection and recovery may occur repeatedly.
The development of blood cells, a process called Hematopoiesis involves two main pathways: myelopoiesis
(the formation of the red and white myeloid cells) and lymphopoiesis (the formation of B- and T-cells).
The genes to be analyzed were selected because of their attributes as key regulators during different stages of hematopoiesis and leukemogenesis, as well as their more or less distinct organ specificity: NCAM1 and RUNX1 as representatives of genes with functions (hematopoiesis, osteogenesis, cell adhesion) on many cell types (hematopoietic cells, neurons, muscles) of various differentiated tissues (embryonic cells, differentiated cells), GATA1 and SPI1 having more circumscribed compartments and cell types (erythropoiesis/megakaryopoiesis, myelopoiesis
, and lymphopoiesis).
ABBREVATIONS: AMKL = acute megakaryoblastic leukemia; AML = acute myelogenous leukemia; BMT = bone marrow transplant; CBC = complete blood count; CMV = cytomegalovirus; RSV = respiratory syncytial virus; TAM = transient abnormal myelopoiesis
Previous reports suggest that these patients present with low blood leukocyte counts, consistent with the impaired myelopoiesis
that can occur with human immunodeficiency virus (HIV) infection.
1989), it is not unexpected that one or more of them may have acted directly, or indirectly via other cells, to lead ultimately to the net negative effect observed on myelopoiesis
(reduction in precursors and, subsequently, their mature granulocyte progeny).