Roberts focused on AML that appears before age 4 years and is preceded by a neonatal preleukemia--transient abnormal myelopoiesis
(TAM)--that only occurs in Down syndrome.
Neutrophil elastase gene (ELANE/ELA-2) mutation is thought to result in a premature endoplasmic reticulum accumulation of unstructured protein in the cell due to increased stress and premature apoptosis in neutrophil precursor cells, thereby suppressing myelopoiesis
Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via [beta]-adrenergic induction of myelopoiesis
Transient leukemia (transient myeloproliferative disorder, transient abnormal myelopoiesis
) of Down syndrome.
Tumor cell lysis syndrome resulting from transient abnormal myelopoiesis
in a neonate with Down's syndrome.
The criteria generally used the same grounds, based on the estimation of the tumor mass parameters in different compartments on the one hand, and the parameters for the assessment of myelopoiesis
on the other hand.
In cancer, tumor-derived factors will cause sustained myelopoiesis
, accumulation, and functional differentiation of myelomonocytic cells .
All these microbial and cellular stimuli work together to sustain steady-state hematopoiesis and also induce emergency myelopoiesis
Schowengerdt Jr., "Tacrolimus: In vitro effects on myelopoiesis
, apoptosis, and CD11b expression," The Journal of Heart and Lung Transplantation, vol.
Liu, "Rosiglitazone promotes bone marrow adipogenesis to impair myelopoiesis
under stress," PLoS One, vol.
Nagareddy et al.'s work  demonstrated that high glucose drives bone marrow myelopoiesis
and promotes diabetes-associated atherogenesis.
It has been implicated as a critical activator of myelopoiesis
in response to pathogen infection and chronic inflammation ; (ii) IL-1[beta] is a potent inflammatory cytokine that mediates leukocytosis and thrombocytosis under inflammatory conditions by inducing various cytokines (i.e., granulocyte colony-stimulating factor and IL-6) .