Olanzapine-induced myoclonic status
. Clin Neuropharmacol.
However, after rewarming from hypothermia, a GCS motor score ≤2 and the presence of myoclonic status epilepticus were not associated with invariably poor outcomes (without a 0% FPR).
After rewarming from hypothermia only, predictors of poor prognosis in comatose patients with hypothermia treatment include the clinical examination (absent pupillary light reflexes, absent corneal reflexes, or presence of myoclonic status epilepticus), EEG (generalized suppression, burst suppression, status epilepticus on EEG, or the absence of EEG reactivity), and neurological biomarkers (48 h NSE ≥81.8 [micro]g/L, 72 h NSE ≥78.9 [micro]g/L, or 48 h S-100B ≥0.3 [micro]g/L) (Recommendation Level A, Evidence Class I).
For the prediction of poor prognosis in comatose patients, appropriate predictors for clinical examination include the presence of myoclonic status epilepticus 24 h after CPR, absent pupillary light reflexes 72 h after CPR, and a GCS motor ≤2 score 72 h after CPR (Recommendation Level A, Evidence Class I).
* bFDA approved for monotherapy and adjunctive therapy for partial seizures, simple and complex absence seizures and as adjunctive therapy for multiple seizures types including absence, photosensitive and generalized tonic-clonic, absence and myoclonic status
epilepticus, status epilepticus
The category of motor response includes myoclonic status
epilepticus, indicating poor prognosis after cardiac resuscitation (25).
In 1/3 of the patients, myoclonic status
picture develops which affects consciousness level.
When pharmacological paralysis and hypothermia were discontinued and sedation decreased a day later, a myoclonic status
began despite treatment with midazolam and phenobarbitone.
A 13-year-old 32 kg male with a past medical history significant for dystonia and learning difficulties was directly admitted to the pediatric intensive care unit for evaluation and treatment of new-onset myoclonic status
Hattemer et al., "Pregabalin-induced generalized myoclonic status epilepticus in patients with chronic pain," Epilepsy and Behavior, vol.
Genton, "Absence and myoclonic status epilepticus precipitated by antiepileptic drugs in idiopathic generalized epilepsy," Brain, vol.
epilepticus has historically been independently associated with poor outcome in coma patients after cardiac arrest [3, 4].