myoglobinuria


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myoglobinuria

[‚mī·ə‚glō·bə′nu̇r·ē·ə]
(medicine)
The presence of myoglobin in the urine.
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References in periodicals archive ?
He has never experienced any McArdle symptoms during or after strength training and has not had myoglobinuria following his gym sessions.
Other publications described proteinuria [7, 14, 15], hematuria [14], and myoglobinuria in malaria patients [10].
Rhabdomyolysis is a severe form of myopathy with muscle breakdown, which leads to myoglobinuria and may result in renal failure and death [2].
"Rhabdomyolysis is a severe form of muscle damage associated with very high creatinine kinase (CK) levels, with myoglobinaemia and/or myoglobinuria with a concomitantly increased risk of renal failure" [4].
In our case, the diagnosis was delayed and our patient experienced myonecrosis with resulting myoglobinuria that required intensive care monitoring and resuscitation but did not progress to acute tubular necrosis.
This causes muscle damage and a distinct increase of creatine kinase (CK) activity in plasma and is associated with renal failure and myoglobinuria [58].
Our patient presented with symptoms of rhabdomyolysis including myalgia and myoglobinuria and was subsequently diagnosed with polymyositis, based on the features of magnetic resonance imaging and muscle biopsy.
During the patient's stay in the ward, her urine was noted to have a red-brown color not explained by myoglobinuria because creatine kinase was only slightly increased at 229 U/L (reference interval 20-180 U/L).
Other features include hypotension, sinus tachycardia, cardiac arrhythmias, convulsions, rhabdomyolysis, myoglobinuria.
On day 3 of admission, several additional abnormalities occurred; serum ALT and AST were elevated (205 U/L and 425 units/L respectively) (n= upto 4ou/L), renal functions became abnormal (BUN 110 mg/dL, creatinine 1.9mg/dL [upto 1.0 mg/dL]), and he had hyperglycaemia, myoglobinuria, proteinuria and haematuria.
Poisoning with PPDA when ingested presents with severe cervicofacial oedema, rhabdomyolysis and intravascular haemolysis leading to myoglobinuria and hemoglobinuria culminating in acute renal failure (ARF).6,7 There is no specific antidote to PPDA and it is non-dialyzable.