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Related to Myopathy: Mitochondrial myopathy


Any disease of the muscles. Also known as myopathia.



progressive muscular dystrophy; a hereditary disease.

Myopathies can be transmitted as autosomal recessive or dominant, or sex chromosome-linked traits. Myopathies result from metabolic disturbances in muscle cells and a change in the biosynthesis of nucleic acids; the degradation of muscle proteins is considerably more rapid than their biosynthesis. In myopathies, muscles become flaccid and some of the fibers are replaced by fatty tissue. Electron microscopy reveals structural changes in the membranes of muscle cells. The main symptoms of the disease are increasing muscular weakness, symmetrical muscular atrophy, decrease in tendon reflexes and, in the later stages, bone and joint deformity. Autonomic trophic nerve functions are invariably impaired.

Myopathy is treated with anticholinesterase preparations, anabolic hormones, and vitamins B and E. Preventive measures include early diagnosis and detection of the heterozygous carrier state for the myopathy gene by using electrophysiological and biochemical tests.


Badalian, L. O., V. A. Tabolin, and Iu. V. Vel’tishchev. Nasledstvennye bolezni u detei. Moscow, 1971.
Hausmanowa-Petrusewicz, I. Myshechnye zabolevaniia. Warsaw, 1971. (Translated from Polish.)


References in periodicals archive ?
Occasionally, the diagnosis may lean heavily on the absence of another cause of the myopathy.
The patient is currently feeling well with no evidence of malignancy, myopathy, and resolution of his cutaneous ADM lesions.
Other limitations of the study included the lack of agreement in incidence of myopathy between RCTs and population-based studies, as well as the likelihood that the risk of diabetes increases with age and higher statin dose--effects not accounted for in the study.
Coenzyme Q10 and selenium in statin-associated myopathy treatment.
He said: "Luke has a form of myopathy in his chest and hips which he means he can't walk or get himself up from a lying position.
Alcoholic neuropathy is a possibility in this case, but alcohol-induced type-2 fiber atrophy, muscle necrosis, or alcoholic myopathy (5) was not evident in the biopsy.
Cases of myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with HMG-CoA reductase inhibitors, including LIVALO.
EMG was reported to be within normal limits, however, the muscle biopsy revealed inflammatory myopathy with mild muscle damage.
Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS syndrome) is a rare, multi-system disorder caused by deficient production of adenosine triphosphate (ATP) due to mitochondrial dysfunction (1).
A rare side-effect of simvastatin is muscle weakness, known as myopathy,
Statin use was associated with a hightened risk of liver dysfunction, acute kidney failure, myopathy, and cataracts.
Diagnosing drug-induced myopathy can be challenging, particularly as individual drugs may have different clinical presentations in different patients.