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Related to Myopathy: Mitochondrial myopathy


Any disease of the muscles. Also known as myopathia.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



progressive muscular dystrophy; a hereditary disease.

Myopathies can be transmitted as autosomal recessive or dominant, or sex chromosome-linked traits. Myopathies result from metabolic disturbances in muscle cells and a change in the biosynthesis of nucleic acids; the degradation of muscle proteins is considerably more rapid than their biosynthesis. In myopathies, muscles become flaccid and some of the fibers are replaced by fatty tissue. Electron microscopy reveals structural changes in the membranes of muscle cells. The main symptoms of the disease are increasing muscular weakness, symmetrical muscular atrophy, decrease in tendon reflexes and, in the later stages, bone and joint deformity. Autonomic trophic nerve functions are invariably impaired.

Myopathy is treated with anticholinesterase preparations, anabolic hormones, and vitamins B and E. Preventive measures include early diagnosis and detection of the heterozygous carrier state for the myopathy gene by using electrophysiological and biochemical tests.


Badalian, L. O., V. A. Tabolin, and Iu. V. Vel’tishchev. Nasledstvennye bolezni u detei. Moscow, 1971.
Hausmanowa-Petrusewicz, I. Myshechnye zabolevaniia. Warsaw, 1971. (Translated from Polish.)


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Other posters included presentations on the TAZPOWER design, TAZPOWER data, primary mitochondrial myopathy natural history, primary mitochondrial myopathy open-label extension data, and MMPOWER primary mitochondrial myopathy Phase 1/2 metabolomics data.
Antibody-positive patients are most likely having an autoimmune myopathy that is progressive and persists after drug with drawal.
It may be suggested that myofibers in group B couldn't preserve their orientation because of potential mechanisms underlying the statin induced myopathy. Myofibers of group C showed slight variability in orientation as compared to group B; being united in 83.3% specimen and split in 6.7% specimens.
The primary endpoints of the six-month, parallel-design study are change in distance walked (metres) as measured by the six-minute walk test and change in the Total Fatigue score on the Primary Mitochondrial Myopathy Symptom Assessment (PMMSA), a patient-reported outcome measure.
Nerve conduction study showed left ulnar compression mononeuropathy at the elbow of moderate severity as well as mild left-sided carpal tunnel syndrome with no evidence of left-sided C5-T1 radiculopathy Electromyography (EMG) showed no evidence of myopathy (including inflammatory myopathy) in the left deltoid, biceps, brachioradialis, extensor indicis muscle, extensor digitorum muscle, flexor digitorum profundus, adductor pollicis brevis, right deltoid, right rectus femoris, and iliopsoas muscle.
The first signs are often lethargy, a quiet demeanour or reluctance to work and the most common misdiagnosis in cases of Atypical Myopathy is colic, as the first stages can appear very similar.
Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene.
In general, the skeletal muscle pathology of FLNC myopathy is mainly manifested as muscular dystrophy, with abnormal protein aggregation and rimmed vacuoles in muscle fibers, as well as lack of specificity in clinical symptoms.
The main symptoms of hypothyroidism myopathy include weakness, cramps, muscular pain, decreased reflexes and myoedema (4).
The clinical spectrum of myopathy ranges from an asymptomatic increase in the concentration of creatine kinase to myalgia, myositis, and rhabdomyolysis.
Patients in the 0-5 age group represented 41.2% of all investigations, and the most common three diagnoses obtained in this group were as follows: 28.6% plexopathy, 7.4% polyneuropathy (PNP) and 6.6% myopathy.