nalidixic acid


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nalidixic acid

[¦nal·ə¦dik·sik ′as·əd]
(pharmacology)
C12H12N2O3 Pale buff, crystalline powder; melting point is 229-230°C; soluble in chloroform and in potassium hydroxide and sodium hydroxide solutions; used as an antibacterial drug in humans and animals.
References in periodicals archive ?
To determine the antibiogram of the isolated strains, we selected different antibiotics like ampicillin, nitrofurantoin, tetracycline, cefotaxime, nalidixic acid, ciprofloxacin, co-trimoxazole, meropenem, imipenem, chloramphenicol, gentamicin and piperacillin-tazobactum (16).
The numbering system of compounds from left to right is as follows: piroxicam (7), nalidixic acid (6), cinoxacin (8), difloxacin (3), enrofloxacin (10), pefloxacin (4), ofloxacin (1), lomefloxacin (9), ciprofloxacin (2), and pipemidic acid (5).
Resistance to nalidixic acid alone or in combination with other drugs was observed in 24% and 17.6% of isolates from eastern and central regions, respectively.
Evaluation of the current trend of Nalidixic Acid succeptibility in typhoidal Salmonella; a marker of therapeutic failure for the fluoroquionolones.
[less than or 6-15 >15 equal to]5 Ampicillin 57 8 28 Trimothprim/ sulfamethoxazole 94 16 50 Nalidixic acid 98 17 46 Norfloxacin 64 11 30 Cefotaxime 5 0 5 Cefixime 9 0 8 [less than or 6-15 >15 equal to]5 Ampicillin 50 8 23 Trimothprim/ sulfamethoxazole 93 0 41 Nalidixic acid 88 18 40 Norfloxacin 16 4 10 Cefotaxime 10 3 3 Cefixime 8 2 3 Note: Table made from bar graph.
Overall resistance to FQs tested was almost similar: moxifloxacin (74.4%) ciprofloxacin (79.3%), sparfloxacin (80.1%), ofloxacin (80.3%), norfloxacin (80.9%) and enoxacin (81.8%) with greater resistance to nalidixic acid (91.7%).
Nalidixic acid have maximum of all biological activities, but H-6 showed slightly better antioxidant activity than Nalidixic acid and other activities were close to it.
In vitro antibacterial activity of AM-715, a new nalidixic acid analog.
Among 88 isolates, 72.7% were nalidixic acid resistant Salmonella (NARS) which include Salmonella Typhi (58, 78.4%) and Salmonella Paratyphi (6, 42.9%).
There were intermittent zones of inhibition to the claforan, nalidixic acid, amoxycillin, fosfomycin, fortum, and erythromycin (Table 3).