OVA-challenged mice showed a significant increase (p < 0.05) in nasal lavage
fluid IL-4, IL-5, IL-13, IL-17, and IFN-I3 levels as compared to normal mice.
Lindahl, "PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage
fluid," Biochemical Society Transactions, vol.
Blood and Nasal Lavage
Samples Preparation and Analysis.
Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage
fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight.
. Nasal lavage
was carried out using a method previously described (Noah and Becker 2000) by repetitive spraying of sterile normal saline irrigation solution (4 mL total) into the nostril, followed by voluntary expelling of fluid by the subject into a specimen collection cup.
Other outcomes included nasal lavage
eosinophil count and ECP levels.
Analysis of the nasal lavage
samples supported the clinical findings of chronic nasal inflammation among the WTC-exposed cohort.
The researchers concluded, "It seems possible that the ES SAL [endoscopic surgery with serial antimicrobial lavage] program may be applicable to other disease states predisposed to chronic refractory infectious sinusitis." Nevertheless, ESSAL still involves surgery, which could be avoided if nasal lavage
could alleviate symptoms on its own.
We followed exhaled nitric oxide, nasal NO, lung functions, cytokines [tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin-4 (IL-4), IL-6, and IL-12] and NO in nasal lavage
fluid (NAL) during and after the exposures.
Treatment with aspirin during aspirin desensitization has been reported to lower the level of leukotriene C4 in nasal lavage
fluid of aspirin-sensitive patients.
In the 37 patients treated after inoculation, viral titers and IL-8 concentrations in nasal lavage
fluid were lower than those following placebo, they said (JAMA 281:1797-1804, 1999).
Techniques to study potential health effects include multiple methods to study the impact of pollutants on the respiratory tract, including acoustic thinometry, nasal peak inspiratory flow, nasal scraping, nasal lavage
, olfactory testing, and trigeminal nerve sensory acuity.